Gastric Cancer Prevention in the Family Members by Helicobacter Pylori Eradicatio
Not Applicable
Active, not recruiting
- Conditions
- Certain infectious and parasitic diseases
- Registration Number
- KCT0006742
- Lead Sponsor
- ational Cancer Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Active, not recruiting
- Sex
- All
- Target Recruitment
- 3100
Inclusion Criteria
Sibling or offspring of patients with gastric adenocarcinoma confirmed by EGD and biopsy
- Age: 40-65 years
- Informed consent should be signed
Exclusion Criteria
- Gastric cancer history
- Other malignancy within the past 5 years
- Hereditary cancer family member (HNPCC, FAP)
- Peptic ulcer history
- Peptic ulcer, esophageal cancer, gastric cancer case found at EGD
-H. pylori eradication treatment history
- Previous serious side effect to antibiotics
-Serious concurrent infection or nonmalignant disease such as liver cirrhosis, renal failure, cardiovascular diseases
-Pregnant or nursing women
-Psychiatric disorder that would preclude compliance, alcoholics
-Refuse informed consent
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of gastric cancer
- Secondary Outcome Measures
Name Time Method Gastric dysplasia incidence;Gastric cancer incidence between H. pylori treatment and H. pylori uninfected groups;Gastric cancer incidence according to H. pylori status;All-cause mortality