Information processing, neuropsychological, and neurobiological processes in pediatric obsessive-compulsive disorder.
Completed
- Conditions
- - Cognitive Behavioral Therapy (CBT) (16 weekly sessions)- Waitlist (8 weeks), followed by CBT (16 weekly sessions)- For neurobiological measures there is a healthy control group.
- Registration Number
- NL-OMON20975
- Lead Sponsor
- Academic Medical Centre (AMC), Amsterdam
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 45
Inclusion Criteria
1. Children and adolescents 8 - 18 years;
2. Primary diagnosis: Obsessive Compulsive Disorder (OCD);
3. OCD symptoms for more than 6 months;
4. CY-BOCS total score > 16;
5. IQ > 80;
6. Informed consent of parents and child.
Exclusion Criteria
Use of the following medication:
1. SSRI;
2. TCA;
3. Anti-psychotic medication.
For neurobiological measures (fMRI):
1. Claustrophobia;
2. Metal on body.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Severity of OCD (CY-BOCS; measured at the start of the waitlist condition, directly before start of the CBT, session 4, 8, 12 and 16 and follow up after 16 weeks);<br>2. Anxiety / Depression (RCADS) measured at the start of the waitlist, directly before start of the CBT, at the end of the therapy (session 16) and follow up after 16 weeks).
- Secondary Outcome Measures
Name Time Method 1. Information-processing (explicit: OBQ-44 R, MCQ-A; Implicit: EAST) (measured at the start of the waitlist, directly before start of the CBT, session 8 and 16 and follow up after 16 weeks);<br>2. Inhibition / selective attention (Dot Probe; measured at the start of the waitlist, directly before start of the CBT, session 8 and 16 and follow up after 16 weeks);<br>3. Neuroimaging data: volumes grey and white matter, activity on planning (tower of London), selective attention (Flanker) and inhibition (DOT-probe)task in fMRI.