The Plasticity of Social Brain Network in Adults With Autism Spectrum Disorder
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Autism Diagnostic Interview Revised, ADIR
研究概览
简要总结
"Social brain" refers to brain regions dedicated to processing social information and enabling us to recognize and evaluate others' mental states. The social brain hypothesis suggests that our brains evolve to navigate complex social systems. The social brain is hypothesized to consist of a distributed network including the posterior superior temporal sulcus (pSTS), the dorsal and ventral medial prefrontal cortices (dmPFC and vmPFC), ACC and posterior cingulate cortex (PCC), the amygdala, the orbital frontal cortex (OFC), and the fusiform gyrus (FG), TPJ, inferior occipital gyrus (IOG), and the insula. Each region serves distinct role while works together to support social processing, including perceiving, interpreting, and generating responses to the intentions, dispositions, and behaviors of others.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age between 18 and 50
- •diagnosed with ASD from licensed mental health or medical professional based on DSM5
- •have social problems
- •motivated to participate in the treatment
- •fluent in chinese
- •caregiver also fluent in chinese and motivated to participate
- •had a full-scale IQ > 70 on WAIS-IV
- •scored ≧ 26 on the caregiver-reported Autism Spectrum Quotient (AQ), indicating clinical impairment associated with ASD.
排除标准
- •history of major mental illness, such as bipolar affective disorder, schizophrenia, psychosis, or neurological diseases
- •visual impairment and/or hearing impairment
- •any metal, electronic part that cannot be removed from the body, or being pregnant, which may not be able to use fMRI scan.
研究组 & 干预措施
ASD group
autistic adolescents with their caregiver
干预措施: PEERS (Behavioral)
Control group
healthy control without their caregiver
干预措施: PEERS (Behavioral)
结局指标
主要结局
Autism Diagnostic Interview Revised, ADIR
时间窗: 16 weeks
Interview of the caregivers that covers most developmental and behavioral aspects of ASD. Range from 0 to 8, higher the score, worse the symptom.
The Empathy Quotient (EQ)
时间窗: 16 weeks
40 items, total score range from 0 to 80. Higher the score, worse the empathy
The Autism Diagnostic Observation Schedule, ADOS
时间窗: 16 weeks
Diagnosing and assess autism. Range from 0 to 8, higher the score, worse the symptom.
Autism Spectrum Quotient
时间窗: 16 weeks
50 items, total score range from 0 to 50. Higher the score, worse the symptom
Social Responsiveness Scale, Second Edition (SRS-2)
时间窗: 16 weeks
65 items, total score range from 65 to 260. Higher the score, worse the symptom
Quality of Socialization Questionnaire (QSQ)
时间窗: 16 weeks
12 items, total score range from 0 to 12.Higher the score, better the frequency and quality of socialization
次要结局
未报告次要终点