on-invasive ultrasound-based quantification of perfusion parameters, fibrosis, inflammation and steatosis in paediatric patients after liver transplantatio

Not Applicable

• Conditions: Z94.4; Liver transplant status

• Registration Number: DRKS00034751
• Lead Sponsor: niversitätsklinikum Tübingen, Radiologie, Abteilung für Diagnostische und Interventionelle Radiologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-07-23
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Status after liver transplantation
- Clinically indicated liver biopsy
- Referral for ultrasound examination of the liver
- Written informed consent from patient (depending on developmental stage) and legal guardian

Exclusion Criteria

- Non-compliance by the patient
- No written consent from patient / legal guardian

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation of sonographic parameters with results of histopathological examination of transplant liver biopsies

Secondary Outcome Measures

Name	Time	Method
To evaluate novel sonographic methods for characterisation of liver and spleen tissue with quantification of perfusion parameters, fibrotic changes, steatosis and signs of inflammation/rejection.<br>To establish sonography as an alternative/supplement to established invasive techniques for classification of liver parenchymal changes.