Sacral distribution pattern of bone mass and fat marrow by quantitative CT- and MRI-analysis considering bone mineral density

Recruiting

• Conditions: M81.90; S32.1; Fracture of sacrum

• Registration Number: DRKS00029319
• Lead Sponsor: BG Klinikum Bergmannstrost Halle gGmbH

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-07-12
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

all groups: CT and MRI (including mDixon quant – sequence) of the pelvis
- PaInNo: intact pelvises, no osteoporosis
- PaInO: intact pelvises, osteoporosis
- PaFrO: unilateral fractures of the sacrum, osteoporosis

Exclusion Criteria

- all groups: missing mDixon quant –sequence, implants oder metastasis in the pelvis
- PaInNo: fractures of the sacrum, osteoporosis
- PaInO: fractures of the sacrum, no osteoporosis
- PaFrO: no/bilateral/transverse fractures of the sacrum, no osteoporosis

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Description of the zonal differences in bone mass and fat marrow content in the sacrum between bone-healthy and osteoporotic pelvises and a bilateral comparison in unilaterally fractured sacra.<br>Determination of the relationship between bone mass and fat marrow with regard to the distribution pattern along the transsacral corridors.<br>Measurement parameter of the bone mass is the CT value (in Hounsfield units) and of the fat marrow content is the FatFraction (in %), which is measured in the FatFraction-Map of the mDixon quant sequence. Assessment of bone mineral density using the qCT (for PaFrO) and the CT value measurement in LWK 5 (for PaInNo and PaInO).<br><br>

Secondary Outcome Measures

Name	Time	Method
Improvement of the understanding of the typical fracture course of fragility fractures of the sacrum as well as determination of optimal locations for screw fixation in osteoporotic bone structure. Investigation of the hypothesis that reduced bone structure is replaced by fat in osteoporosis.