Program of vascular evaluation under uric acid control by xanthine oxidase inhibitor, febuxostat: multicenter, randomized controlled study (PRIZE) sub study
Not Applicable
- Conditions
- The analysis data set of the main trial will be used as the database of this study.
- Registration Number
- JPRN-UMIN000041322
- Lead Sponsor
- Department of Cardiovascular Medicine, Saga University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 483
Inclusion Criteria
Not provided
Exclusion Criteria
Not applicable
Study & Design
- Study Type
- Others,meta-analysis etc
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Rate of change from baseline after 24 months in the mean IMT value of the common carotid artery determined by carotid artery ultrasound
- Secondary Outcome Measures
Name Time Method 1. IMT, FMD, PWV, CAVI, EF, LVEF, E, A, TRPG, e' and E/e' by treatment group at each measurement point 2. Blood test values (red blood cells, white blood cells, hemoglobin, hematocrit, blood platelet count, AST, ALT, LDH, BUN, Na, K, Cl, blood glucose, serum uric acid level, serum lipids: TC, HDL-C, TG, non-HDL-C, LDL-C, serum creatinine, eGFR), serum biomarker values NT-proBNP, high-sensitivity CRP, 1, 5AG, small dense LDL, RLP-C, MDA-LDL, serum cystatin C, RAGE, high-molecular adiponectin, high-sensitivity troponin I, ANGPTL2, Alb, Ca, FGF23, P), and urine test values (urinary albumin excretion, urinary L-FABP) by treatment group at each measurement point