EUCTR2011-006090-25-EE
Active, Not Recruiting
N/A
The Impact of Heart Rate on Central Hemodynamics of Antihypertensive Therapy
Tartu Ülikooli kardioloogiakliinik0 sitesDecember 29, 2011
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Tartu Ülikooli kardioloogiakliinik
- Status
- Active, Not Recruiting
- Last Updated
- 11 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age 18\-75 years
- •Dual chamber (atrium and ventricle) cardiac pacemaker placed due to sick sinus syndrome (at least 1 month after implantation)
- •Good atrioventricular conductance (PQ interval \< 250 msec)
- •Study subject has signed the informed consent form
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1\.2 Adults (18\-64 years) yes
- •F.1\.2\.1 Number of subjects for this age range 30
- •F.1\.3 Elderly (\>\=65 years) yes
- •F.1\.3\.1 Number of subjects for this age range 70
Exclusion Criteria
- •Patients with contraindication or intolerance to beta\-blockers, ivabradine, or their adjuvants
- •Use of antiarrythmic drugs (sotalol, amiodarone, propafenone)
- •History of several episodes of atrial fibrillation
- •Use of antibiotics
- •Acute or chronic inflammatory diseases
- •Resting blood pressure \< 110/70 mmHg
- •Atrioventricular conductance disorders (patient needs permanent pacing)
- •Long QT interval on resting ECG
- •Severe liver or kidney disorder
- •Pregnant or breast\-feeding women
Outcomes
Primary Outcomes
Not specified
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