A Comparison Of Dexmedetomidine And Lignocaine In Managing The Intraocular Pressure And Heamodynamic Changes Post Suxamethonium Administration, Laryngoscopy, And Tracheal Intubation In Cancer Surgeries.

Not yet recruiting

• Conditions: Neoplasms,

• Registration Number: CTRI/2025/06/088785
• Lead Sponsor: Dr. Anjana Vinod

Brief Summary

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|This randomized prospective comparitive study aims to compare the effectiveness of intravenous Dexmedetomidine (group-D) 0.5mcg/kg and intravenous Lignocaine (group-L) 1.5mg/kg in attenuating rise in IOP as an indicator of attenuating hemodynamic response following administration of suxamethonium laryngoscopy and intubation in ASA I and ASA II patients undergoing elective oncological surgeries under general anesthesia.  The baseline values, pre-induction, post-induction (1 min, 3 mins and 5 mins)  of intra-ocular pressure(IOP), non-invasive blood pressure(NIBP), mean arterial pressure(MAP), and heart rate(HR) are measured and compared in both the groups. Adverse effects such as Hypotension, Bradycardia, Arrythmias, etc in either groups will also be noted. During the whole perioperative period heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure, oxygen saturation and ECG will be monitored and documented as per standard protocol and patient will be shifted to ICU for further monitoring.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2025-06-13
• Study Start: 2025-06-30

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients aged between 18 and 65 years.
• (and) Patients belonging to ASA physical status grade 1 and 2.
• (and) Patients consenting for study.

Exclusion Criteria

• Patient’s refusal (or) Patients with severe cardiac, respiratory and renal disease.
• (or) Patients with known neurological disorder.
• (or) Patients with preexisting ocular diseases or history of eye surgery.
• (or) Pregnant or breastfeeding females.
• (or) Known allergy or contraindications to either lignocaine or dexmedetomidine.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the effect of intravenous dexmedetomidine and intravenous lignocaine for attenuating IOP and hemodynamic response after suxamethonium administration, laryngoscopy and intubation	Baseline values, pre-induction, post-induction (1 minute, 3 minutes, 5 minutes)

Secondary Outcome Measures

Name	Time	Method
To study any adverse effects of intravenous dexmedetomidine and intravenous lignocaine	Intra-operative and post-operative period (upto 24 hours)

Trial Locations

Locations (1)

Kidwai Memorial Institute of Oncology; 🇮🇳 Bangalore, KARNATAKA, India

Kidwai Memorial Institute of Oncology

🇮🇳Bangalore, KARNATAKA, India

Dr Anjana Vinod

Principal investigator

9591434171

anjuvinx@gmail.com