Efficacy of KCl Plus 0.9%NaCl Compare With KCl Plus 0.45%NaCl
Phase 4
- Conditions
- Hypokalemia
- Interventions
- Other: KCl plus 0.45%NaClOther: KCl plus 0.9%NaCl
- Registration Number
- NCT02721095
- Lead Sponsor
- Phramongkutklao College of Medicine and Hospital
- Brief Summary
evaluate efficacy and safety of IV administration of potassium chloride (KCl) plus 0.9%NaCl compare with KCl plus half-strength normal saline solution (0.45%NaCl) in correcting hypokalemia
- Detailed Description
Hypokalemia is frequently encountered in hospitalized patients. Intravenous (IV) potassium repletion with saline is preferred used for initial therapy. However, administration of normal saline (0.9%NaCl) usually provokes sodium and potassium diuresis, thus, it might delay reversal of the hypokalemia.
Object of this study : to evaluate efficacy and safety of IV administration of potassium chloride (KCl) plus 0.9%NaCl compare with KCl plus half-strength normal saline solution (0.45%NaCl) in correcting hypokalemia.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 84
Inclusion Criteria
- Serum K+ 2.5-3.49 mmol/L
- No life threatening condition from hypokalemia
Exclusion Criteria
- Pregnancy
- Volume overload, heart failure
- Hypotension
- Acute kidney injury
- Dysnatremia
- K+ shift
- Salt wasting nephropathy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 0.45%NaCl KCl plus 0.45%NaCl KCl plus 0.45%NaCl 0.9%NaCl KCl plus 0.9%NaCl KCl plus 0.9%NaCl
- Primary Outcome Measures
Name Time Method Number of participants with normal serum K as assessed by serum electrolyte 24 hours
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Phramonkutklao Hospital
🇹ðŸ‡Bangkok, Thailand