Cardiac Function in Severe Aneurysmal Subarachnoid Haemorrhage Patients

Completed

• Conditions: Aneurysmal Subarachnoid Haemorrhage; World Neurosurgeon Federation Score ≥ III
• Interventions: Procedure: Echocardiography

• Registration Number: NCT01801800
• Lead Sponsor: Nantes University Hospital

Brief Summary

Cardiac dysfunction can occur in aneurysmal subarachnoid haemorrhage and might impact patient's neurologic outcome Condition Aneurysmal subarachnoid haemorrhage World Neurosurgeon Federation Score ≥ III

Detailed Description

Trans-thoracic echocardiography on day 1, day 3 and day 7 Speckle-Tracking of echocardiographic loops by a cardiologist blinded to the patient's management and outcome

Study Timeline

• Study Start: 2012-01
• Study First Submitted: 2013-02-15
• Study First Submitted QC: 2013-02-27
• Study First Posted: 2013-03-01
• Primary Completion: 2013-12
• Study Completion: 2013-12
• Status Verified: 2014-05
• Last Update Submitted: 2014-05-09
• Last Update Posted: 2014-05-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Aneurysmal subarachnoid haemorrhage
• World Neurosurgeon Federation Score ≥ III
• Written information to next-of-kin and patients when possible

Exclusion Criteria

• History of myocardial infarction, chronic heart failure with NYHA ≥ 2, major heart surgery
• Lack of acoustic window to perform trans-thoracic echocardiography

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Aneurysmal subarachnoid haemorrhage	Echocardiography	Speckle-tracking images in Echocardiography

Primary Outcome Measures

Name	Time	Method
Neurologic outcome	3 months	modified Rankin Scale (mRS). Poor neurological outcome was considered as death or severe disability (mRS 5-6).

Secondary Outcome Measures

Name	Time	Method
Correlation between cardiac strain on day 1 and Left Ventricular Ejection fraction	Day 1
Correlation between cardiac enzymes (NT-proBNP, troponin T US) and cardiac strain	Day 1
Correlation between EKG findings and cardiac strain	Day 1
Time to amines discontinuation	During Intensive Care Unit stay, expected average 17 days
Duration of mechanical ventilation	Duration of mechanical ventilation, expected average 15 days
Length of ICU stay	Duration of ICU stay, expected average 17 days
Correlation between Cardiac function and Mechanical Ventilation	Day1, day3, day7 and extubation time expected average 15 days
Correlation between Cardiac function and ICU length of stay	Day1, day3, day 7 and end of stay in ICU expected average 17 days

Trial Locations

Locations (1)

University Hospital; 🇫🇷 Rennes, France