Urinary Biomarker Neutrophil Gelatinase Associated Lipocalcin (NGAL) in Early Prediction of AKI in Cirrhosis of Liver
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- To compare urine Neutrophil Gelatinase Associated lipocalcin values in Hepato renal syndrome and Non-Hepato renal syndrome group.
研究概览
简要总结
Kidney dysfunction is a complex and common event in patients with liver cirrhosis. Although novel treatments have shown some promising results , acute kidney injury remains a major complication of decompensated liver cirrhosis with high morbidity and mortality rates . AKI occurs in up to 19-20% of hospitalized patients with liver cirrhosis and among the most frequent causes are prerenal azotemia (PRA), hepatorenal syndrome and acute tubular necrosis , with prevalence rates estimated around 68%, 25%, and 33%, respectively.
The introduction and widespread use of diagnostic criteria of AKI in the area of cirrhosis has contributed to an increased awareness and earlier detection of AKI. However, some important problems remain. One of the main issues is the differential diagnosis of AKI, particularly between acute tubular necrosis (ATN) and hepatorenal syndrome (HRS-AKI). This is important because treatment is different; renal replacement therapy (RRT) is used for the former, and vasoconstrictors and albumin are used for the latter.
详细描述
Aim of the study:
To determine utility of NGAL in chronic liver disease patients with acute kidney injury.
Objective:
- To compare urine NGAL values in HRS and Non-HRS group.
- To determine optimal cutoff of urine NGAL for early determination of HRS.
Plan of investigation:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cirrhosis diagnosis by combination of clinical, laboratorial, endoscopic and imaging
- •Age over 18 years old
- •Acute kidney injury (defined by ICA-AKI criteria)
- •Agreement to participate in the study
排除标准
- •Shock/CCF
- •Age less than 18yrs •
- •Underwent renal replacement therapy within the last 6 week prior to evaluation
- •Prior kidney or liver transplantation
- •Confirmed pregnancy
- •Established CKD
- •Congestive cardiac failure
- •Patients who have taken diuretics in the last 48 hours
结局指标
主要结局
To compare urine Neutrophil Gelatinase Associated lipocalcin values in Hepato renal syndrome and Non-Hepato renal syndrome group.
时间窗: 12 months
Kidney biomarkers appear to be useful in differential diagnosis between acute tubular necrosis (ATN) and other types of acute kidney injury (AKI) in cirrhosis, particularly hepatorenal syndrome (HRS-AKI)
次要结局
- . To determine optimal cutoff of urine NGAL for early determination of HRS.(12 months)
研究者
Mohan Ramchandani
Clinical Professor
Asian Institute of Gastroenterology, India