The clinical study of intercostal nerve pulsed radiofrequency in postherpetic neuralgia

Completed

Conditions: Postherpetic neuraglia (PHN)
Nervous System Diseases
Cranial nerve disorders in diseases classified elsewhere

Registration Number: ISRCTN25588650

Lead Sponsor: Xinhua Hospital (China)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 96

Inclusion Criteria

1. Age greater than 60 years
2. PHN history is longer than 3 months
3. Pain on Visual Analogue Scale (VAS) >3 (0-10 VAS scale)
4. PHN affected nerve sectors were thoracic nerves from T1 to T12 level
5. Refractory to formal treatment such as antiepileptic medicine, antidepressants, opioids and physical treatments and epidural block

Exclusion Criteria

1. Exclusion criteria included withdraws from the study
2. Poor effect, intolerant to the study
3. Uncooperative and unable to finish the self evaluation (VAS, QOL and SF-36)
4. Coagulation disturbances
5. Allergies to local anaesthetic
6. Malignancy

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Visual Analogue Scale (VAS) score, measured at baseline, days 3, 7, 14, 30 and 60, 6 months and 1 year<br>2. Flare pain per day during days 3, 7, 14, 30, 60 and at 6 months<br>3. Neurometer CPT/C (Neurotron, Inc) to measure three fiber function<br>4. SF-36 at baseline, 2 months, 6 months and 1 year following-up

Secondary Outcome Measures

Name	Time	Method
1. Need to PRF again or other invasive operation at 2 day, 6 month or 1 year following-up<br>2. Dosage of rescue drug consumed per week at the end of treatment and after 4 weeks follow-up - including Tramadol and/or acetaminophen - and the dosage of combined drug, anti-depressive drug (amitriptyline)<br>3. Presence, frequency and duration of adverse effects at 7, 14, 30, and 60 days