Ow versus COnventional Tidal Volumes during One-lung Ventilation for Minimally Invasive Esophagectomy - A Randomized Controlled Trial

Completed

• Conditions: Acute Lung Injury; lung damage; 10017991; 10024967; 10017998

• Registration Number: NL-OMON37002
• Lead Sponsor: Atrium Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

patients who will undergo an esophagectomy

Exclusion Criteria

Patients < 18 years
Patients with serious obstructive lung-disease
Patients with NYHA III or IV
Patients with chronic corticosteroid use

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main endpoints of this study are markers of pulmonary inflammation and<br /><br>coagulation, including cytokines and chemokines, neutrophil influx, markers of<br /><br>apoptosis, and markers of coagulation and fibrinolysis in lavage fluids<br /><br>obtained at the beginning and at the end of surgery. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints include duration of postoperative mechanical ventilation,<br /><br>length of stay in intensive care unit and hospital, incidence of postoperative<br /><br>pulmonary complications and mortality.</p><br>