EFFECT OF LOW DOSE DEXAMETHASONE, ON BLOOD SUGAR CHANGES, IN DIABETIC AND NON-DIABETIC PATIENTS UNDERGOING ELECTIVE LOWER ABDOMEN AND LOWER LIMB SURGERIES
- Conditions
- Health Condition 1: K460- Unspecified abdominal hernia withobstruction, without gangreneHealth Condition 2: S729- Unspecified fracture of femurHealth Condition 3: S829- Unspecified fracture of lower leg
- Registration Number
- CTRI/2020/06/025765
- Lead Sponsor
- Kamal Nayan Joshi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 80
1)ASA Grade I & II
2)Superficial lower abdominal or lower limb surgery.
3)Surgeries planned under subarachnoid block
4)Patients with controlled blood sugar levels (FBS <130mg/dl)
5)Age between 30 years - 60 years.
6)Body mass index <= 30kg/m.2
7)Surgery lasting for 1-2 hours.
8)Hospital stay; for at least 48 hours.
1)Patientâ??s refusal.
2)ASA Grade III & IV.
3)Surgeries planned under general anaesthesia.
4)Diabetic patients with blood sugar levels (FBS >130mg/dl).
5)Patients with bleeding diathesis.
6)Patients with electrolyte imbalances.
7)Patients with cardio-respiratory disease.
8)Patients with hepatorenal disease.
9)Patients allergic to the study drug or local anaesthetic.
10)Patients with history of treatment with steroids in last 3 months.
11)Any neuro-psychiatric illness.
12)Pregnancy
13)Obesity (body mass index >30 Kg/m2).
14)Day care surgeries.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.To assess the perioperative blood sugar level changes in diabetic and non-diabetics after administration of single dose dexamethasoneTimepoint: 1.To assess the perioperative blood sugar level changes in diabetic and non-diabetics after administration of single dose dexamethasone
- Secondary Outcome Measures
Name Time Method 1.To assess the time of onset for hyperglycemia in diabetic and non diabetics (if it is there). <br/ ><br>2.To assess the requirement of insulin & dextrose containing fluid. <br/ ><br>3.To assess the hemodynamic parameter changes e.g. heart rate, non-invasive blood pressure, oxygen saturation, and electrocardiogram. <br/ ><br>4.To assess for any adverse outcome during study period. <br/ ><br>Timepoint: Blood sugar levels will be measured hourly up to 3 hours from T0(time of injection dexamethasone) and labelled T1, T2 and T3; then 6 hourly from T0 till next 24 hours and 12 hourly for next 24 hours.