mNGS for Detection of Pathogens for Pulmonary Infection
- Conditions
- Pulmonary Infection
- Registration Number
- NCT03798925
- Lead Sponsor
- Sir Run Run Shaw Hospital
- Brief Summary
Pulmonary infections remain the leading causes of morbidity and mortality among patients worldwide. Pathogen identification is crucial yet difficult for the majority of the cases. Metagenomic Next-generation Sequencing provides a potential technology for rapid and untargeted pathogen detection for pulmonary infection. The study is designed observationally to investigate if mNGS is superior to traditional paradigm of serial tests in the aspect of diagnostic performance. Patients whose primary diagnosis is pulmonary infetion and bronchoalveolar lavage fluid can be obtained will be enrolled. Both mNGS and traditional paradigm of serial tests wil be performed.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
- Pulmonary infection as the primary diagnosis
- Bronchoalveolar lavage fluid can be obtained
- when the primary diagnosis is tumor or connective tissue diseases
- microbiological diagnosis is confirmed before bronchoalveolar lavage
- not enough bronchoalveolar lavage fluid for mNGS
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method microbiological diagnosis (pathogen of pulmonary infection) through study completion, up to 6 months the final microbiological diagnosis (pathogen of pulmonary infection) after using of every detection method and combined with clinical manifestations.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Sir Run Run Shaw Hospital
🇨🇳Hangzhou, Zhejiang, China