TO COMPARE THE EFFICACY OF TWO DIFFERENT DOSES OF DEXMEDETOMIDINE ON HEMODYNAMIC RESPONSE DURING DL AND EI IN PATIENT UNDERGOING LAPROSCOPIC SURGERY UNDER GA. A RANDOMIZED CONTROLLED STUDY
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 发起方
- 入组人数
- 98
- 试验地点
- 1
- 主要终点
- IV Dexmedetomidine 1 mcg/kg is more effective than intravenous Dexmedetomidine 0.75mcg in suppressing pressor response during laryngoscopy and intubation in patients undergoing laparoscopic surgery.
研究概览
简要总结
Secure airway for proper ventilation during anaesthesia is one of the most important component of a successful surgery . Many drugs are used to reduce the hemodynamic stress response during laryngoscopy and endotracheal intubation. The question for ideal drugs and their dosage without major side effects is still pursued . This research aimed to investigate the impact of two different doses of Dexmedetomidine in mitigating the stress response during laryngoscopy and endotracheal intubation. Dexmedetomidine is an alpha-2 receptor agonist and shorter acting than clonidine, is emerging as a promising drug to counteract the catecholamine release.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients between 18 to 60 years of age ASA physical status 1 and 2 with airway Mallampati Grade 1 and 2.
排除标准
- •Refusal pregnant patient on beta blockers morbid patients Full stomach on alpha 2 agonist patient suffering from heartblock or sicksinus syndrome.
结局指标
主要结局
IV Dexmedetomidine 1 mcg/kg is more effective than intravenous Dexmedetomidine 0.75mcg in suppressing pressor response during laryngoscopy and intubation in patients undergoing laparoscopic surgery.
时间窗: Preparatory phase- 2 month | Phase of data collection- 08 months | Phase of data analysis- 02 months | d. Report writing & submission- 02 months
次要结局
- To compare the efficacy of two different doses of Dexmedetomidine on hemodynamic response during direct laryngoscopy & endotracheal intubation in patient undergoing laparoscopic surgery under general anaesthesia(Hemodynamic parameters like the Heart rate systolic & diastolic blood pressure & mean arterial pressure will be measured 15 minutes after drug administration & 1 min 3mins 5mins 10mins 15mins post intubation)
研究者
Hariharan V
ESIC Medical college and hospital