The effect of remote ischemic preconditioning on kidney and cardiac injury after CABG
Phase 2
- Conditions
- Atherosclerotic heart disease.Atherosclerotic heart disease
- Registration Number
- IRCT138903123646N3
- Lead Sponsor
- Vice chancellor for research of Mazandaran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
non-emergency on-pump first time CABG; EF higher than 35% Exclusion criteria: under 18 years of age; CABG with valve surgery; pregnancy; advanced liver disease (INR >2.0); severe renal impairment (Creatinine clearance <50 ml/min); respiratory failure (O2 Sat <90 %); acute myocardial infarction up to 14 days before surgery; advanced peripheral vascular disease affecting the lower limbs; drug therapy with sulfonamide or Nicorandil.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Acute kidney injury. Timepoint: preoperatively and 6, 12, 24 and 48 h postsurgery. Method of measurement: Acute Kidney Injury Network criteria.;Serum Troponin I. Timepoint: 0 , 6 , 12 , 24, 48. Method of measurement: Laboratory kit.
- Secondary Outcome Measures
Name Time Method Atrial fibrilation. Timepoint: After surgery. Method of measurement: Data collecting form.;Dialysis. Timepoint: Before and 6, 12, 24 and 48 hours after surgery. Method of measurement: Data collecting form.;Serum creatinine. Timepoint: Before and 6, 12, 24 and 48 hours after surgery. Method of measurement: laboratory kit.;Serum CRP. Timepoint: Before and 6, 12, 24 and 48 hours after surgery. Method of measurement: Laboratory kit.;Inotrope requirement. Timepoint: 6, 12, 24 and 48 hours after surgery. Method of measurement: Data collecting form.;Ventilator time. Timepoint: After surgery. Method of measurement: Data collecting form.;Length of ICU stay. Timepoint: After surgery. Method of measurement: Data collecting form.;In-hospital mortality. Timepoint: After surgery. Method of measurement: Data collecting form.