Humoral and Cell-mediated Immune Responses and Immunological Tolerance After Rabies Booster Vaccination in Previously Rabies Immunized HIV-infected Adults
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Rabies Neutralizing Antibody Titers (RNab)
研究概览
简要总结
To study the humoral and cell-mediated immune responses in HIV-infected adults who had previously received rabies booster vaccination more than a year before
详细描述
Previous study has shown the higher immunogenicity response among HIV-infected adults who received a single visit 4-site intradermal rabies booster vaccination than those who received the conventional intramuscular regimen. The investigators follow the persistence of these effects. Also, the regulatory T cell levels were examined after the rabies booster vaccination .
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Healthy HIV-infected adults
- •Previously received rabies booster vaccination by participation in the previous clinical trials of the investigators.
排除标准
- •Have any active opportunistic infections
- •Received blood or blood product within 3 months
- •Received anti-malarial drugs
- •Received rabies vaccination in a previous year.
结局指标
主要结局
Rabies Neutralizing Antibody Titers (RNab)
时间窗: GMTs of RNab and proportion of volunteers who have had RNab above protective antibody levels (0.5 IU/ml) after receipt of rabies booster vaccination at least a year before were compared between 2 arms at one time point on the date of study recruitment.
Rabies Neutralizing Antibody Titers would be represented and compared by geometric mean titers (GMTs)
次要结局
- Rabies specific T cell response(Numbers of spots, of which represent the rabies specific T cell response after receipt of rabies booster vaccination at least a year before were compared between 2 arms at one time point on the date of study recruitment.)
研究者
Suda Sibunruang
Medical doctor
Queen Saovabha Memorial Institute