Comparison of Effects of Scalp Block and Intravenous Esmolol on Hemodynamic Response Following the Skull Pins Application for Elective Supratentorial Craniotomy
Not Applicable
Completed
- Conditions
- Hemodynamic Instability
- Interventions
- Procedure: Scalp block
- Registration Number
- NCT06268275
- Lead Sponsor
- Khon Kaen University
- Brief Summary
The goal of this clinical trial is to compare hemodynamic response (MAP, SBP, DBP and HR) between scalp block and intravenous esmolol while skull pins application in patients undergoing elective supratentorial craniotomy under general anesthesia.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
- Age 18-65 years old
- BMI 18-30 kg/m2
- American Society of Anesthesiologists (ASA) status I-III
- Elective supratentorial craniotomy under general anesthesia
- Required application of skull pins
Exclusion Criteria
- Poor controlled hypertensive condition (Baseline BP ≥ 160/110 mmHg)
- Thrombocytopenia / Coagulopathy
- Preoperative atrioventricular block (More than 2nd degree AV block)
- Emergency surgery
- Posterior fossa / Intracranial aneurysm surgery
- Pregnancy
- Chronic use of pain control
- Contraindication to beta-blockers
- Allergy to the drugs used in the study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group S Scalp block Receive 30 ml of 0.25% bupivacaine with 1% lidocaine (1:1) with adrenaline 1:200,000 infiltration for 10 minutes before skull pins application. Group E Esmolol Receive intravenous esmolol 1 mg/kg bolus over 1 minute before skull pins application.
- Primary Outcome Measures
Name Time Method MAP Baseline, 1 minute before skull pins, then 30 sec, 60 sec, 90 sec, 120 sec, 180 sec and 300 sec after skull pins Mean arterial pressure
SBP Baseline, 1 minute before skull pins, then 30 sec, 60 sec, 90 sec, 120 sec, 180 sec and 300 sec after skull pins Systolic blood pressure
DBP Baseline, 1 minute before skull pins, then 30 sec, 60 sec, 90 sec, 120 sec, 180 sec and 300 sec after skull pins Diastolic blood pressure
HR Baseline, 1 minute before skull pins, then 30 sec, 60 sec, 90 sec, 120 sec, 180 sec and 300 sec after skull pins Heart rate
- Secondary Outcome Measures
Name Time Method BIS Baseline, 1 minute before skull pins, then 30 sec, 60 sec, 90 sec, 120 sec, 180 sec and 300 sec after skull pins Bispectral index
Cumulative postoperative opioids consumption 6 hours and 24 hours postoperatively Opioids consumption
Postoperative adverse events Within first 24 hours postoperatively Incidence (%)
Trial Locations
- Locations (1)
Khon Kaen University
🇹🇭Khon Kaen, Naimuang, Muang, Thailand