Negative Postprandial Effect on Endothelium After a Not-healthy Meal in Type 2 Diabetes as Affected by Training

Not Applicable

Completed

• Conditions: Diabetes Mellitus, Type 2
• Interventions: Behavioral: 47 min moderate intensity training; Behavioral: exercise healthy volunteers; Behavioral: control; no exercise training

• Registration Number: NCT01991769
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

The purpose of this study is to examine whether exercise reduces the postprandial effects of an unhealthy meal on heart function and endothelial function.

Both healthy people and type 2 diabetes subjects will during three days either carry out two different sessions of exercise training or not before ingesting an unhealthy meal high in saturated fat and fast carbohydrates. The two different exercise training modes used are high intensity interval training (HIIT) and moderate intensity training (MIT) Hypothesis: Exercise training in advance of an unhealthy meal will improve endothelial- and cardiac function in healthy and type 2 diabetes individuals. HIIT will reduce the negative postprandial effects on the endothelium more than MIT.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-02
• Primary Completion: 2012-12
• Study First Submitted: 2013-10-28
• Study Completion: 2013-11
• Study First Submitted QC: 2013-11-18
• Study First Posted: 2013-11-25
• Status Verified: 2016-06
• Last Update Submitted: 2016-06-13
• Last Update Posted: 2016-06-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• healthy or type 2 diabetes

Exclusion Criteria

• type 2 diabetes more than 10 years
• unstable angina
• myocardial infarction
• overt cardiovascular disease.
• severe valvular disease.
• overt lung disease.
• orthopedical- /neurological restrictions
• severe disease related to diabetes type 2 (neuropathy, micro-or macroalbuminuria, retinopathy)
• body mass index >35
• severe eating disorders.
• personality disturbances.
• planned surgery during the project period.
• patients who achieve greater than the current exercise guidelines for type 2 diabetes (210 min/week) before the start of the study.
• uncontrolled hypertension
• kidney failure
• cardiomyopathy
• smoking
• patients who probably not will be able to complete the study
• alcohol or drug abuse

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
exercise diabetes type 2	47 min moderate intensity training	4x4 min interval training, 47 min moderate intensity training, or no exercise preceding an 'unhealthy' meal.
exercise diabetes type 2	control; no exercise training	4x4 min interval training, 47 min moderate intensity training, or no exercise preceding an 'unhealthy' meal.
exercise healthy volunteers	control; no exercise training	4x4 min interval training, 47 min moderate intensity training, or no exercise preceding an 'unhealthy' meal.
exercise diabetes type 2	exercise healthy volunteers	4x4 min interval training, 47 min moderate intensity training, or no exercise preceding an 'unhealthy' meal.
exercise healthy volunteers	47 min moderate intensity training	4x4 min interval training, 47 min moderate intensity training, or no exercise preceding an 'unhealthy' meal.
exercise healthy volunteers	exercise healthy volunteers	4x4 min interval training, 47 min moderate intensity training, or no exercise preceding an 'unhealthy' meal.

Primary Outcome Measures

Name	Time	Method
endothelial function	24 hours	measured as flow mediated dilatation (FMD) of the brachial artery using high resolution vascular ultrasound according to current guidelines

Trial Locations

Locations (2)

Forskningsposten, St Olavs Hospital; 🇳🇴 Trondheim, Norway

ISB; 🇳🇴 Trondheim, Norway