Effect of Exercise-Induced Weight Loss on Energy Metabolism

Completed

• Conditions: Metabolism; Weight Loss

• Registration Number: NCT01775163
• Lead Sponsor: Pennington Biomedical Research Center

Brief Summary

The E-MECHANIC Ancillary Study will measure changes in 24-hour energy expenditure and spontaneous physical activity in a subset of 60 obese individuals enrolled in the main study. We aim to determine if changes in energy metabolism might explain why people don't lose the expected amount of weight in an exercise program.

Detailed Description

This is an ancillary study to E-Mechanic, which is an National Institutes of Health study in 198 individuals with the objective to understand why certain people fail to lose weight in exercise programs. In E-Mechanic changes in body weight, body composition, energy intake and energy expenditure are measured before and after 3 different exercise programs of 24 weeks in duration. The 3 exercise programs being compared are self-directed exercise, low dose exercise and high dose exercise. The goal of this ancillary study is to undertake comprehensive assessments of energy metabolism in a metabolic chamber in a group of 60 obese individuals enrolled in the main study. We will compare differences in the changes in 24h energy expenditure and spontaneous physical activity between the 3 exercise programs. We will also test if changes in energy metabolism might explain why people don't lose the expected amount of weight after 24 weeks of exercise.

Study Timeline

• Study Start: 2010-12
• Study First Submitted: 2013-01-22
• Study First Submitted QC: 2013-01-22
• Study First Posted: 2013-01-24
• Primary Completion: 2015-02
• Study Completion: 2015-02
• Status Verified: 2021-08
• Last Update Submitted: 2021-08-23
• Last Update Posted: 2021-08-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

• Individuals enrolled in the E-MECHANIC main study (NCT#01264406) with a body mass index (BMI) greater than or equal to 30 kg/m2.

Exclusion Criteria

• Not enrolled in the E-MECHANIC main study (NCT#01264406).
• Have a body mass index (BMI) less than 30 kg/m2.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in 24h energy expenditure	24 weeks	24h energy expenditure will be measured in a room calorimeter before and after a 24 week exercise program

Secondary Outcome Measures

Name	Time	Method
Metabolic adaptation in 24h energy expenditure	24 weeks	The difference between the actual change in 24 energy expenditure and the energy expenditure estimated on the basis of body size will be compared between: 1) exercise groups and 2) between individuals who lost the expected amount of weight and individuals who did not lose the expected amount of weight during the exercise program

Trial Locations

Locations (1)

Pennington Biomedical Research Center; 🇺🇸 Baton Rouge, Louisiana, United States