Metabolic adverse events before and after glucocorticoid pulse therapy in rheumatoid arthritis

Withdrawn

• Conditions: 10018424; 10003816; rheumatic disease; rheumatoid arthritis; 10023213

• Registration Number: NL-OMON35669
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 15

Inclusion Criteria

Rheumatoid arthritis exacerbation, defined by Disease Activity Score of 5.1 or higher.

Exclusion Criteria

Patients with diabetes
Patients with clinical contra-indication for pulse therapy
Patients with DMARD changes during the last month

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Metabolic disturbances<br /><br>-Physical examination: weight, blood pressure<br /><br>-Laboratory examination: fasting lab with a.o. an OGTT and lipid profile</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Disease activity<br /><br>-Interview:<br /><br>oVisual Analogue Scale (VAS)-pain, VAS-well being<br /><br>-Physical examination:<br /><br>oTender joint score<br /><br>oSwollen joint score<br /><br>-Laboratory examination:<br /><br>oFasting with a.o. ESR and hemoglobin<br /><br><br /><br>Cardiovascular risk factors<br /><br>-Interview:<br /><br>Smoking, alcohol use, diabetes (family history), lipid disorder, hypertension,<br /><br>cardiovascular disease (family history, events), sports/activities (with<br /><br>questionnaire Short QUestionnaire to ASses Health enhancing physical activity).<br /><br>-Physical examination:<br /><br>Waist- en hip circumference, ankle-arm index with Doppler machine. </p><br>