The Role of Smoking and Gingival Crevicular Fluid Markers on Coronally Advanced Flap Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 主要终点
- Change in the percentage of root coverage
研究概览
简要总结
Cigarette smoking is a patient-related factor that can affect healing of periodontal tissues and the success rate of root-coverage procedures. Neither the nature nor the mechanisms of action of cigarette smoking on root coverage are fully understood. Therefore, the hypothesis that cigarette smoking has negative impacts on the outcomes of root coverage after CAF surgery in systemically healthy individuals with an initial gingival thickness of at least 0.8 mm and who practice optimal oral hygiene was tested. It was also hypothesized that baseline analysis of disease-related biomarkers would shed light on the underlying mechanisms of a possible effect.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Maxillary central and lateral incisors, canines, and premolars and mandibular premolars with isolated buccal recessions classified as Miller Class I or II
- •Study tooth should present tooth vitality, identifiable cemento-enamel junction (CEJ) and absence of caries, restorations or extensive non-carious cervical lesion.
排除标准
- •Medical disorders such as diabetes mellitus, immunologic disorders, hepatitis
- •History of previous mucogingival surgery at the gingival recession site
- •Medications known to affect gingival tissues
- •Antibiotic treatment in the past 6 months
- •Pregnancy or lactation
结局指标
主要结局
Change in the percentage of root coverage
时间窗: 1-month, 3-month and 6-month after coronally advanced flap (CAF)
Root coverage were measured on digital photographs using specific software.
次要结局
- Change in the percentage of complete root coverage(1-month, 3-month and 6-month after coronally advanced flap (CAF))
- Change in gingival thickness(Baseline,1-month, 3-month and 6-month after coronally advanced flap (CAF))
- Changing of the gingival crevicular fluid (GCF) biomarkers(Baseline,1-month, 3-month and 6-month after coronally advanced flap (CAF))
- Changing of the salivary biomarkers(Baseline,1-month, 3-month and 6-month after coronally advanced flap (CAF))
- Change in the visual analog scale (VAS) values(1 to 7 day after coronally advanced flap (CAF))
研究者
Nurcan Buduneli
Clinical Professor
Ege University