Efficacy of Structured Exercise-Nutritional Intervention on Sarcopenia in Patients With Osteoporosis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sarcopenia
- Sponsor
- Kowloon Hospital, Hong Kong
- Enrollment
- 13
- Locations
- 1
- Primary Endpoint
- Grip strength
- Status
- Completed
- Last Updated
- 7 months ago
Overview
Brief Summary
This is a prospective parallel group, double-blinded randomized controlled trial. Subjects are randomized into two groups - the intervention group and waitlist control group. Subjects received resistance, aerobic, flexibility and balance exercise training; and nutritional supplement containing β-hydroxy β-methylbutyrate (HMB). The intervention group would first receive the intervention during the 12-week study period. Meanwhile, the waitlist control group would receive 12 weeks of conventional care. After the study period, they would receive the same intervention.
Investigators
Leung Hin Cheung
Principal Investigator
Kowloon Hospital, Hong Kong
Eligibility Criteria
Inclusion Criteria
- •Diagnosis of sarcopenia:
- •Low hand grip strength (Male: \<28 kg, Female: \<18 kg) AND
- •Low appendicular skeletal mass by bioimpedance analysis (Male: \<7.0 kg/m2 Female: \<5.7 kg/m2)
- •Diagnosed with osteoporosis by:
- •Fragility fracture or
- •T-score ≤-2.5 SDs at any site based upon BMD measurement by Dual Energy X-ray Absorptiometry (DXA) scan
Exclusion Criteria
- •Incompetent in giving consent or following commands
- •Non-ambulatory subject
- •Unstable medical conditions contributing to sarcopenia, for example but not limited to:
- •End stage organ failure
- •Unstable cardiovascular, respiratory, gastrointestinal and endocrine conditions
- •Active malignancy
- •Chronic kidney disease stage IV or above or with hyperkalaemia
- •Diabetes mellitus on medications or with unstable control
- •Terminal illness
- •Obese subjects (BMI ≥ 25.0)
Outcomes
Primary Outcomes
Grip strength
Time Frame: 12 weeks
Grip strength was measured with Jamar Plus+ digital hand dynamometer (Performance Health Supply, Wisconsin, United States).
Secondary Outcomes
- Body weight(12 weeks)
- Body mass index(12 weeks)
- 5-time chair stand test(12 weeks)
- Appendicular skeletal muscle mass index(12 weeks)
- 6-metre walk test(12 weeks)
- Short Physical Performance Battery (SPPB)(12 weeks)