TO EVALUATE THE EFFCT OF ORAL IVABRADINE FOR ATTENUATION OF HEMODYNAMIC FOLLOWING LARYNGOSCOPY AND INTUBATION IN PATIENT UNDERGOING ELECTIVE SURGERY UNDER GENERAL ANAESTHESIA
Not Applicable
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2022/11/046943
- Lead Sponsor
- SIKKIM MANIPAL INSTITUTE OF MEDICAL SCIENCES
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All American Society of Anaesthesiology (ASA) physical status I, aged 18-
50 yrs posted for elective non cardiac surgery under general anaesthesia
requiring endotracheal intubation who consent to be part of the study
Exclusion Criteria
1. Patient not giving consent for the study.
2. ASA status >II
6
3. Anticipated difficult intubation(Mallampati Class III and IV,
thyromental height < 6 cm , inter-incisor distance <3cm and cervical
instability.
4. Baseline heart rate < 60 b/min or >90 b/min
5. Baseline BP <90/50mm Hg (65) or >140/85mm Hg (105)
6. History of syncope, palpitation, chest pain or cardiac/ respiratory
illness, liver or renal dysfunction.
7. History of substance abuse.
8. Those with ECG abnormalities.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method the change in heart rate, blood <br/ ><br>pressure and MAP (mean arterial pressure) following laryngoscopy and <br/ ><br>intubation, which shall be compared between the study and control group. <br/ ><br>Unattenuated these changes can be 20% or more.Timepoint: 24 hours of total study duration in each case starting from the oral intake of study drug.
- Secondary Outcome Measures
Name Time Method To assess incidence of side effects and complication if any due to study drugTimepoint: 24 hrs in postoperative period after intake of study drug