The Effect of Ivabradine on Patients With Postural Tachycardia Syndrome
- Registration Number
- NCT01761825
- Lead Sponsor
- Tel-Aviv Sourasky Medical Center
- Brief Summary
The purpose of this study is to determine whether Ivabradine is an effective treatment for postural tachycardia syndrome.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
-
Patients diagnosed with POTS by the following criteria:
- The presence of characteristic orthostatic symptoms of the POTS for at least six months.
- An increase in the heart rate of at least 30 beats per minute (without concomitant significant decrease in blood pressure of more than 20/10 mmHg) within 10 minutes after assuming a standing position (or during tilt test) on at least 3 separate occasions.
- No other concomitant diseases that could explain the symptoms of POTS.
Exclusion Criteria
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- History of systemic illness capable of affecting of affecting autonomic function (eg, diabetes mellitus, SLE).
- History of cardiovascular disease.
- History of smoking, drug or alcohol abuse.
- Pregnancy, and also uncontrolled thyroid or adrenal disorders.
- Using any drug metabolized by cytochrome P450 3A4 enzyme during the last 72 hours.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Ivabradine ivabradine Ivabradine 10 mg once
- Primary Outcome Measures
Name Time Method the change in heart rate after the administration of Ivabradine 60 minutes , during the whole trial the change in blood pressure after the administration of Ivabradine 60 minutes
- Secondary Outcome Measures
Name Time Method