Identification of disease susceptibility genes associated with development and clinical characteristics of primary inflammatory muscle diseases, polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM)

Manchester University (UK)0 个研究点目标入组 1,947 人开始时间: 2010年9月21日最近更新: 2021年2月16日

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•1. Skin lesions of (DM):
•1.1. Heliotrope rash (violaceous rash and on upper eyelids)
•1.2. Gottron?s sign (violaceous keratotic macules on extensor aspect of finger joints)
•1.3. Violaceous slightly raised rash over elbows/knees
•2. Proximal muscle weakness (PM, DM and IBM)
•3. Elevated plasma muscle enzymes
•4. Myalgia, at rest or with contraction
•5. Myopathic changes on electromyogram (EMG)
•6. Anti Jo1 Ab
•7. Nondestructive arthritis
•8. Systemic inflammatory signs (fever, erythrocyte sedimentation rate [ESR] greater than 20, elevated C-reactive protein [CRP], weight loss)
•9. Myositic changes on muscle biopsy
•10. Additional patients with proven Inclusion Body Myositis (IBM)
•11. Male and female, lower age limit of 18 years

•1. Below the age of 18 years
•2. Myositis secondary to:
•2.1. Alcohol or drug abuse
•2.2. Non-abusive drug ingestion (e.g with statins, fibrates etc), or
•2.3. A recent viral illnesses
•3. Unable to give consent due to diminished mental capacity or inability to speak sufficient English
•4. Unwilling to give blood samples

发起方

Manchester University (UK)