ISRCTN28639298
Active, not recruiting
未知
Identification of disease susceptibility genes associated with development and clinical characteristics of primary inflammatory muscle diseases, polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM)
Manchester University (UK)0 sites1,947 target enrollmentSeptember 21, 2010
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Manchester University (UK)
- Enrollment
- 1947
- Status
- Active, not recruiting
- Last Updated
- 5 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Skin lesions of (DM):
- •1\.1\. Heliotrope rash (violaceous rash and on upper eyelids)
- •1\.2\. Gottron?s sign (violaceous keratotic macules on extensor aspect of finger joints)
- •1\.3\. Violaceous slightly raised rash over elbows/knees
- •2\. Proximal muscle weakness (PM, DM and IBM)
- •3\. Elevated plasma muscle enzymes
- •4\. Myalgia, at rest or with contraction
- •5\. Myopathic changes on electromyogram (EMG)
- •6\. Anti Jo1 Ab
- •7\. Nondestructive arthritis
Exclusion Criteria
- •1\. Below the age of 18 years
- •2\. Myositis secondary to:
- •2\.1\. Alcohol or drug abuse
- •2\.2\. Non\-abusive drug ingestion (e.g with statins, fibrates etc), or
- •2\.3\. A recent viral illnesses
- •3\. Unable to give consent due to diminished mental capacity or inability to speak sufficient English
- •4\. Unwilling to give blood samples
Outcomes
Primary Outcomes
Not specified
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