A genetic follow up study in Turner syndrome

Withdrawn

• Conditions: patients with 45; Patients with Turner syndrome; X.; 10083624

• Registration Number: NL-OMON34852
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 85

Inclusion Criteria

Patients with Turner syndrome who have been participating in one of the following studies: MEC: GHTUR/BPD/13NL and MEC: GHTUR/BPD/12NL (the inclusion criteria of the original protocols are described in the protocol at page 14).

Exclusion Criteria

The exclusion criteria are those of the original protocols: MEC: GHTUR/BPD/13NL and MEC: GHTUR/BPD/12NL ((the exclusion criteria of the original protocols are described in the protocol at page 15).

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The frequency of hidden mosaicism, including Y chromosomal material, in 45,X<br /><br>females. The effects of different GH regimens will be analyzed to a background<br /><br>of genotypic variation of the sex chromosomes and the growth hormone receptor.<br /><br>The clinical parameters (aortic diameter and distensibility, congenital cardiac<br /><br>malformations, lipid profile, final height and final height gain) are already<br /><br>assessed in the original studies.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable.</p><br>