Turner syndrome minipuberty study

Recruiting

• Conditions: Turner syndrome; 10038608; 10014701; 10013356

• Registration Number: NL-OMON54918
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

In order to be eligible to participate in the TS group of this study, a subject
must meet all of the following criteria:
- A diagnosis of TS before the age of three months;
- Girls with a diagnosis of classic TS or other variants (i.e. 45,X,
45,X/46XiXq, 45,X/46,XY, 45,X/46,XX, 45,X/47,XXX, 45,X/46,X,r(X), 46,XiXq,
other);
- Whose parents have agreed to participate in the study through a signed
written informed consent form.

In order to be eligible to participate in the control group of this study, a
subject must meet all of the following criteria:
- No diagnosis of TS or any other diagnosis that might affect the HPG axis;
- Girls that will have a blood collection within their usual care at 3 months
and at 9 months of age.
- Whose parents have agreed to participate in the study through a signed
informed consent form.

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded
from participation in this study:
- Any other diagnosis besides TS that might affect the HPG axis;
- Ovarian surgery in the medical history;
- Critical illness;
- The use of medication affecting the HPG axis (e.g. estrogen suppletion
therapy)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Serum levels of FSH, LH, AMH, estradiol, inhibin B and testosterone.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-</p><br>