Effects of butyrAte comPared to donor faeces transPlantation on mETabolIsm and saTiEty in patients with metabolic syndrome
Completed
- Conditions
- insulin resistance, overweight, gutmicrobiota
- Registration Number
- NL-OMON26960
- Lead Sponsor
- AMC-uvA
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 24
Inclusion Criteria
Caucasian male or postmenopausal female
- 50-70 years old
Exclusion Criteria
-Any Medication use, including PPI and antibiotics in last 3 months
- Drug abuse
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Insulin sensitivity and lipolysis (2-step hyperinsulinemic euglycemic clamp)<br /><br> - Hypothalamic (SPECT-scan), small intestinal (biopsy) and urinal (24h urine sample) serotonin levels in relation to satiety testing
- Secondary Outcome Measures
Name Time Method - Faecal energy excretion and short chain fatty acid and bile acid concentration in feces<br /><br>- Dietary intake (dietary lists), resting energy expenditure (calorimetry) and physical activity energy expenditure (accelerometers) <br /><br>- Faecal and small intestinal gut microbiota composition (morning stool samples and biopsies)<br /> <br>- Intestinal permeability (faecal calprotectin levels)<br /> <br>- Intestinal passage time (Sitzmark capsules)<br /><br>- Sympathetic tone (Nexfin)<br /><br>- Inflammatory and lipid-proteomic markers (blood samples) <br /><br>- Liver fat for NAFLD/NASH degree (MRI)