Effect of adding dexmedetomidine to local anaesthetic wound infiltration for post surgery pain relief
- Conditions
- Other intraoperative and postprocedural complications and disorders of digestive system,
- Registration Number
- CTRI/2019/02/017736
- Lead Sponsor
- Svims
- Brief Summary
An incision made in the abdominal wall contributes to severe postoperative pain which may cause the decreased function of the immune system, decreased healing and painful suffering, these changes may probably negatively affect the postoperative recovery pain.
Wound infiltration with local anesthetics is one of the multimodal approaches to control postoperative pain after open abdominal surgeries.
Ropivacaine is a long-acting amide– local anesthetic, s-enantiomer mainly used for surgery and postoperative pain relief.4 At high doses, it produces surgical anesthesia and at lower doses, it produces analgesia mainly sensory block with a limited and non-progressive motor block. Ropivacaine has a slightly prolonged duration of action than bupivacaine and less cardiotoxic effects.
Dexmedetomidine is a strong and highly selective α2-adrenoreceptor agonist which has sedative, analgesic, and sympatholytic properties. It enhances the analgesic efficacy of local anesthetics when added as an adjuvant for wound infiltration.
Different doses of dexmedetomidine has been tried as adjuvant to local anaesthetics to prolong post operative analgesia.6,7,8However the optimum dose of dexmedetomidine is yet to be
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 90
- 1.Patients scheduled to undergo elective open abdominal surgeries at SVIMS.
- 2.Patients belonging to ASA physical status 1,2 and 3.
- 3.Age group between 18 and 65 years.
- 1.Patient refusal to participate in the study.
- 2.Severe hepatic/cardiac/renal disorders.
- 3.Pre existing neurological deficits/psychiatric illness/metabolic disorders.
- 5.History of chronic analgesic usage(on oral analgesics for more than one month).
- 6.Pregnant and lactating mothers.
- 7.Patients who cannot understand and interpret NRS.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The magnitude of pain using NRS at fixed time interval At 0hr,2hr,4hr,6hr,12hr&24hr.
- Secondary Outcome Measures
Name Time Method Analgesic requirement in first 24 hours after surgery. The time to the first request of rescue analgesia.
Trial Locations
- Locations (1)
svims
🇮🇳Chittoor, ANDHRA PRADESH, India
svims🇮🇳Chittoor, ANDHRA PRADESH, IndiaDrSumadhuPrincipal investigator9177704349sumadhu13121991@gmail.com