to study intraperitoneal use of clonidine(alpha agonist), as additive to local anaesthetic) for postoperative pain relief and sideeffects after abdominal uterus removal
Not Applicable
Completed
- Conditions
- Health Condition 1: null- ASA I & II patients aged 35 to 60 yrs for elective total abdominal hysterectomy after ruling out use of adrenoreceptor agonists,antagonists or narcotics before surgery, hypersensitivity to study drug.Health Condition 2: N998- Other intraoperative and postprocedural complications and disorders of genitourinary system
- Registration Number
- CTRI/2016/12/007544
- Lead Sponsor
- Mata Chanan Devi Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
•60 ASA grade I and II female patients
•Age between 35 to 60 years
•scheduled for elective total abdominal hysterectomy surgery under general anaesthesia.
•Patient willing to give written informed consent for participation in the study.
Exclusion Criteria
1) Patients with â?? ASA grade 3 or above.
2) Age more than 60 yrs or less than 35 yrs. 3) Patients with morbid obesity, Raynaudâ??s disease.
4) Patients receiving adrenoreceptor agonists,antagonists, or narcotics before operation.
5) Patientâ??s refusal to participate in the study.
6) Known hypersensitivity to the study drug
7) H/o cardiovascular, respiratory, hepatic, renal, neurological or endocrine disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To determine the analgesic efficacy of clonidine in wound infiltration with bupivacaine and to compare the same with Intravenous administration in terms of postoperative analgesic requirement and side-effects (nausea, sedation, bradycardia and hypotension)Timepoint: for heart rate and blood pressure- at peritoneal closure, 15,30,45,60,90,120 minutes after it. <br/ ><br>for pain,sedation,nausea- at post anaesthesia care unit arrival,2,4,6,12,24hours after it
- Secondary Outcome Measures
Name Time Method Dose of opioid neededTimepoint: over first 24 hours.;Time of opioid requirementTimepoint: noted for first 24 hours postoperatively.