PhotoDynamic Therapy for Line Infection Prevention (PLIP): Pilot Study on Normal Volunteers
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 10
- Primary Endpoint
- Evaluation of the skin microbiome after methylene blue treatment
Study Overview
Brief Summary
We are evaluating the effect of methylene blue and visible light activation on the microbiome of the skin.
Detailed Description
Antiseptics are routinely utilized to prevent infections of vascular catheters. We are evaluating the addition of methylene blue and light activation on skin to determine whether this inexpensive and non-toxic treatment can decrease skin pathogens and prevent blood stream infections of long-term vascular catheters. This is a pilot study of normal volunteers to determine the effect on the microbiome of the addition of methylene blue and light activation on antiseptic-treated skin.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 21 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Normal individuals without skin problems
Exclusion Criteria
- •Diabetics
- •Atopic dermatitis
- •G-6-PD deficiency
- •Other skin conditions
- •Allergies to methylene blue or chlorhexadine
Outcomes
Primary Outcomes
Evaluation of the skin microbiome after methylene blue treatment
Time Frame: 1 week
We compared the two arms of each subject --one arm treated with chloraprep and a biopatch \[routine treatment of skin\] to the routine treatment with the addition of methylene blue spray and light activation. The microbiome of both skin areas were assessed before and after the routine treatment and the treatment with the addition of methylene blue therapy;
Secondary Outcomes
No secondary outcomes reported
Investigators
Jeanine Wiener-Kronish
Chief of Anesthesia
Massachusetts General Hospital