Study of diet for tolerance induction with food allergy children. Randomized controlled trial to evaluate efficacy of low dose ingestion of responsible food for children with food allergy.
Not Applicable
- Conditions
- Food allergy (Hen's egg,cow's milk,wheat)
- Registration Number
- JPRN-UMIN000019671
- Lead Sponsor
- Showa university school of medicine,Department of pediatrics
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 52
Inclusion Criteria
Not provided
Exclusion Criteria
1)The patients who cannot be obtained informed consent by themselves or their guardians. 2)The threshold for eliciting positive symptoms is less than or equal to a thirty-second hen's egg,3ml of cow's milk, or 3g of Udon noodles by oral food challenge test. 3)Patiens with a history of anaphylactic shock caused by oral food challenge test(hen's egg,cow's milk,or wheat) or ingestion of those by mistake. 4)The patiens with poorly controlled asthma or atopic dermatitis. 5)The patient who the attending physician determines inappropriate.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference of threshold of tolerance dose after treatment between low dose ingestion of responsible food on alternate days and complete elimination for food allergy.
- Secondary Outcome Measures
Name Time Method 1)Desensitization of food allergy 2)The change of antigen-specific antibody IgE and IgG4 in serum,and result of skin prick test. 3)The change of quarity of life by questionnaire. 4)Incidence of bronchial asthma.