Protein synthesis rates of muscle and bone tissue in femoral bone fracture patients.

Completed

Conditions: Eiwitmetabolisme in verschillende musckuloskeletale weefsels
Hip fracture
proximal femoral fracture
10017322

Registration Number: NL-OMON49997

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 12

Inclusion Criteria

1) Written informed consent;
2) Recent (<24 h before admission to the hospital) femoral bone fracture
requiring hip replacement surgery;
3) Admitted to MUMC+ to receive a femoral head-neck prosthesis or total hip
replacement.

Exclusion Criteria

1) Physical restlessness due to delirium;
2) Rheumatoid arthritis;
3) Chemotherapy or radiotherapy;
4) (Multiple) Myeloma or other primary cancer tumor with possible bone
metastasis;
5) Collagen disorders, e.g. Marfan and Ehler-Danlos;
6) Any other medical condition that may interfere with the safety of the
subjects or the outcome parameters, in the investigators judgement;
7) Investigator*s uncertainty about the willingness or ability of the subject
to comply with the protocol instructions;
8) Participation in any other studies involving investigational or marketed
products concomitantly to entry into the study.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome parameters are bone protein synthesis rates in the femoral<br /><br>shaft and femoral head tissue, expressed in FSR (%/h). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary outcome parameters are tissue-specific protein synthesis rates in<br /><br>femoral bone, femoral head cartilage, hip synovium, and skeletal muscle,<br /><br>expressed in FSR (%/h). In addition, plasma enrichments of<br /><br>L-[ring-13C6]-phenylalanine is a secondary outcome parameter.</p><br>