Fibrinogen and albumin synthesis rates in major upper abdominal surgery

Not Applicable

Completed

• Conditions: iver disease; Liver disease; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon; Surgery - Other surgery

• Registration Number: ACTRN12617000749303
• Lead Sponsor: Karolinska Institutet

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-05-22
• Study Completion: 2019-06-03
• Last Update Posted: 21 February 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Patients with indications and admited for elective major hepatic surgery or distal pancreatic resections

Exclusion Criteria

1.No consent
2.A surgical procedure that deviates from the standard hemihepatecomy, extended hemihepatectomy, or the standard Whipple´s procedure.
3.Any condition that the investigator find to be in potential conflict with the 3 standard procedures intended to be studied.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in fibrinogen absolute synthesis rate assessed by isotopic techniques linked with detection by mass spectrometry.<br>[Baseline(preoperatively), postoperative day 1 , postoperative day 3-5]

Secondary Outcome Measures

Name	Time	Method
Change in albumin absolute synthesis rate assessed by isotopic techniques linked with detection by mass spectrometry.[Baseline(preoperatively), postoperative day 1, postoperative day 3-5 ];To explore if the absolute and fractional synthesis rates of fibrinogen and albumin, assessed by isotopic techniques linked with detection by mass spectrometry., correlate following hemihepatectomy and extended hemihepatectomy[Baseline(preoperatively), postoperative day 1, postoperative day 3-5 ]