Effects of Memantine on fatigue in patients with Multiple sclerosis
Phase 1
Completed
- Conditions
- Multiple sclerosis.Multiple sclerosis
- Registration Number
- IRCT2016121231362N1
- Lead Sponsor
- Iranian Center of Neurological Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 64
Inclusion Criteria
A history of multiple sclerosis (MS) for more than one year; Type of MS was Relapsing Remitting (RR); Subjective fatigue (grade 3 or 4 fatigue based on questionnaires); Age of 20-55 years; Expanded Disability Status Scale (EDSS): 0-5; Consent to participate in the study.
Exclusion criteria: Use of Modafinil, Ritalin or Amantadine; A history of seizure and kidney disease; Taking selective serotonin reuptake inhibitors (SSRI); Other types of diseases.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Fatigue. Timepoint: before intervention, 3 months after start of intervention. Method of measurement: MFIS Questionnaire.
- Secondary Outcome Measures
Name Time Method Depression. Timepoint: before intervention, 3 months after start of intervention. Method of measurement: Beck II questionnaire.;Cognitive disorders. Timepoint: before intervention, 3 months after start of intervention. Method of measurement: MACFIMS test.;Disability. Timepoint: before intervention, 3 months after start of intervention. Method of measurement: EDSS test.