Severe Male Factor Infertility Management
Not Applicable
- Conditions
- Oligoasthenoteratozoospermia
- Interventions
- Other: Antioxidant (l-cratinine) + modifiable lifestyle factors
- Registration Number
- NCT02752555
- Lead Sponsor
- Benha University
- Brief Summary
This study is the first to evaluate the effect of oral supplementation with antioxidants combined with lifestyle modification for severe male factor partner of couples undergoing ICSI.
- Detailed Description
Patients underwent a therapy of a three-month period of treatment with either oral L-carnitine only (2g daily) or oral carnitine (2g daily) combined with modifiable lifestyle factors.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 60
Inclusion Criteria
- Long protocol for ovulation
- Oligoasthenoteratozoospermic male partner ( (count < 0.5 million/ml, Motility=< 40% Progressive motility =<10 %, Abnormal forms >99%).
- Fresh semen samples.
Exclusion Criteria
- Day 3 embryo transfer
- Incomplete ICSI cycles
- Endometrial thickness> 7mm
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Antioxidant+modifiable lifestyle factors Antioxidant (l-cratinine) + modifiable lifestyle factors In the study group, all patients underwent a double-blind therapy of a six-month period of treatment with oral carnitine (2g daily) combined with modifiable lifestyle factors. Patients were requested to follow a healthy standard diet, avoid excessive heat exposure, avoid or minimize exposure to pollutants, and stop smoking, coffee, alcohol, and drugs uptake.After this period, all patients will undergo conventional ICSI.
- Primary Outcome Measures
Name Time Method Implantation rate one month Clinical pregnancy rate two weeks
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (3)
Dar Almaraa fertility and gynacology center
🇪🇬Cairo, Egypt
Nile badrawi Hospital
🇪🇬Cairo, Egypt
Elite fertility care center
🇪🇬Cairo, Egypt