Oxygenation by 100% Oxygen Via High Flow Nasal Cannula in Surgical Patients

Not Applicable

Completed

• Conditions: Anesthesia, Intravenous; Anaesthesia, General; Ventilation
• Interventions: Procedure: Hyperventilation

• Registration Number: NCT02706431
• Lead Sponsor: Karolinska University Hospital

Brief Summary

Oxygenation with high-flow nasal cannula with 100% oxygen has only been evaluated in a limited number of studies. Although data are convincing it is of importance to evaluate this new concept in our department before implementing it into clinical practice.

The general purpose of this project is to evaluate a new ventilation strategy during ENT-surgery based on oxygenation with high-flow nasal cannula with 100% oxygen with focus on gas exchange.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-12-01
• Study First Submitted: 2015-12-15
• Study First Submitted QC: 2016-03-07
• Study First Posted: 2016-03-11
• Primary Completion: 2016-06-30
• Study Completion: 2016-09-01
• Status Verified: 2017-12
• Last Update Submitted: 2017-12-17
• Last Update Posted: 2017-12-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 31

Inclusion Criteria

1. Adult, >18 years old
2. ENT-surgery where apnea is of benefit for the surgeon (eg. intraoral or laryngeal surgery) and the anesthesia time is <40 mins.
3. Capable of understanding the study information and sign the written consent.

Exclusion Criteria

1. ASA>2
2. NYHA >2
3. BMI >30
4. Pregnancy
5. Manifest cardiac failure or coronary disease
6. Neuromuscular disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Hyperventilation	Hyperventilation	Prior to anesthesia, the patients will hyperventilate during 2 mins or until symptoms from the central nervous system (e.g. dizziness).

Primary Outcome Measures

Name	Time	Method
Change in arterial oxygen tension (pO2)	From start of anaesthesia to end of apnoea oxygenation or max 30 minutes
Change in arterial pH	From start of anaesthesia to end of apnoea oxygenation or max 30 minutes
Change in arterial carbon dioxide (pCO2)	From start of anaesthesia to end of apnoea oxygenation or max 30 minutes

Secondary Outcome Measures

Name	Time	Method
Does hyperventilation prior to anaesthesia and apnoea oxygenation cause any difference in pCO2 in the end of the apnea (i.e. at up to 30 minutes) compared to normoventilation?	In the end of the apnoea period, i.e. at approximately 20 minutes
Does hyperventilation prior to anaesthesia and apnoea oxygenation cause any difference in pO2 in the end of the apnea (i.e. at up to 30 minutes) compared to normoventilation?	In the end of the apnoea period, i.e. at approximately 20 minutes
Does the high oxygen content cause atelectasis measures as change in relation between pCO2 and end tidal carbon dioxide	Until discharge from the postoperative unit, often max 2 hours
Does hyperventilation prior to anaesthesia and apnoea oxygenation cause any difference in pH in the end of the apnea (i.e. at up to 30 minutes) compared to normoventilation?	In the end of the apnoea period, i.e. at approximately 20 minutes