Erythropoietin and coronary collateral flow in patients with coronary artery disease

Conditions: angina
myocardial ischemia
10011082

Registration Number: NL-OMON31082

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 110

Inclusion Criteria

Group A
• Men and women > 18 years of age
• A positive stress test or symptoms related to stable CAD
• Patients who are scheduled for an elective PCI for 1 significant stenotic lesion ;Group B:
• Men and women > 18 years of age
• Patients with an acute coronary syndrome, defined as having unstable angina with elevated troponins
• During the coarse of the PCI procedure it has become clear that a single occlusion needs to be revascularised.;Group C:
• Men and women > 18 years
• Patients who are seen at the outpatient clinic and in whom cardiac disease is excluded
• Exclusion of cardiac disease is established by laboratory tests, electrocardiogram, echocardiography and/or an exercise test.

Exclusion Criteria

Group A and B:;• Previous myocardial infarction
• Previous CABG
• Signs of AMI on ECG
• Moderate renal failure (eGFR <50ml/min)
• Concomitant inflammatory or malignant disease
• Presence of other serious medical conditions
• Unwillingness to sign informed consent;group C:;• Moderate renal failure (eGFR <50ml/min)
• Concomitant inflammatory or malignant disease
• Presence of other serious medical conditions
• Unwillingness to sign informed consent

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To assess the correlation between endogenous EPO levels and coronary collateral<br /><br>flow</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secundary objectives are:<br /><br>- to assess if there are differences in endogenous EPO leves, EPC levels and<br /><br>EPC function in patients with stable and unstable CAD, compared to age and sex<br /><br>matched controls;<br /><br>- to explore the correlation between the number of functional EPCs and the<br /><br>extent of coronary collateral flow in patients with stable and unstable angina;<br /><br>- to study the effect of resolving the coronary artery stenosis on endogenous<br /><br>EPO and EPC levels/function before and after the PCI procedure.</p><br>