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A Study of Bleximenib in Combination With Acute Myeloid Leukemia (AML) Directed Therapies

First Posted Date
2022-07-12
Last Posted Date
2025-08-17
Lead Sponsor
Janssen Research & Development, LLC
Target Recruit Count
200
Registration Number
NCT05453903
Locations
🇺🇸

The University of Alabama at Birmingham, Birmingham, Alabama, United States

🇺🇸

City of Hope, Duarte, California, United States

🇺🇸

Massachusetts General Hospital, Boston, Massachusetts, United States

and more 29 locations

SKLB1028, Daunorubicin, and Cytarabine in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia (AML)

Phase 1
Recruiting
Conditions
Newly Diagnosed Acute Myeloid Leukemia (AML)
Interventions
Drug: SKLB1028 Dose Escalation
First Posted Date
2022-07-06
Last Posted Date
2022-07-06
Lead Sponsor
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Target Recruit Count
58
Registration Number
NCT05445154
Locations
🇨🇳

West China Hospital of Sichuan University, Chengdu, China

CART-38 in Adult AML and MM Patients

Phase 1
Terminated
Conditions
Acute Myeloid Leukemia (AML)
Multiple Myeloma (MM)
Interventions
Drug: 3x10(6) CART-38 cellls
Drug: 7x10(5) CART-38 cells
Drug: 7x10(6) CART-38 cells
Drug: 3x10(7) CART-38 cells
First Posted Date
2022-07-05
Last Posted Date
2025-06-26
Lead Sponsor
University of Pennsylvania
Target Recruit Count
11
Registration Number
NCT05442580
Locations
🇺🇸

University of Pennsylvania, Philadelphia, Pennsylvania, United States

A Study to Assess Change in Disease State in Adult Participants With Acute Myeloid Leukemia (AML) Ineligible for Intensive Chemotherapy Receiving Oral Venetoclax Tablets in Canada

Recruiting
Conditions
Acute Myeloid Leukemia
First Posted Date
2022-06-21
Last Posted Date
2025-08-11
Lead Sponsor
AbbVie
Target Recruit Count
270
Registration Number
NCT05424562
Locations
🇨🇦

Tom Baker Cancer Centre /ID# 248113, Calgary, Alberta, Canada

🇨🇦

University of Alberta Hospital /ID# 251531, Edmonton, Alberta, Canada

🇨🇦

BC Cancer - Surrey /ID# 257515, Surrey, British Columbia, Canada

and more 17 locations

AZA + Venetoclax as Maintenance Therapy in Younger Adults With AML in First Remission

Phase 2
Recruiting
Conditions
Acute Myeloid Leukemia (AML) in Remission
Interventions
Other: Supportive care
First Posted Date
2022-06-03
Last Posted Date
2022-08-19
Lead Sponsor
The First Affiliated Hospital of Soochow University
Target Recruit Count
124
Registration Number
NCT05404906
Locations
🇨🇳

First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China

🇨🇳

The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou, Jiangsu, China

A Study of Mitoxantrone Hydrochloride Liposome Injection in Subjects With Acute Myeloid Leukemia

Phase 1
Terminated
Conditions
Relapsed or Refractory Acute Myeloid Leukemia (AML)
Interventions
First Posted Date
2022-04-26
Last Posted Date
2024-02-23
Lead Sponsor
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Target Recruit Count
1
Registration Number
NCT05345938
Locations
🇨🇳

Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Study of Liposomal Annamycin in Combination with Cytarabine for the Treatment of Subjects with Acute Myeloid Leukemia (AML)

Phase 1
Active, not recruiting
Conditions
Leukemia, Myeloid, Acute
Interventions
First Posted Date
2022-04-08
Last Posted Date
2024-12-20
Lead Sponsor
Moleculin Biotech, Inc.
Target Recruit Count
63
Registration Number
NCT05319587
Locations
🇮🇹

Istituto Scientifico Romagolo per lo studio dei umori "Dino Amadori" (IRST) - IRCCS, Meldola, FC, Italy

🇮🇹

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy

🇮🇹

Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy

and more 6 locations

A Study to Assess Change in Disease State in Adult Participants With Acute Myeloid Leukemia (AML) Ineligible for Intensive Chemotherapy Receiving Oral Venetoclax Tablets in Greece

Recruiting
Conditions
Acute Myeloid Leukemia
First Posted Date
2022-04-07
Last Posted Date
2025-07-16
Lead Sponsor
AbbVie
Target Recruit Count
100
Registration Number
NCT05317494
Locations
🇬🇷

Olympion General Clinic /ID# 268392, Patras, Achaia, Greece

🇬🇷

General Hospital of Athens Gennimatas /ID# 245968, Athens, Attiki, Greece

🇬🇷

General Hospital of Athens Laiko /ID# 244338, Athens, Attiki, Greece

and more 10 locations

Pyronaridine in Acute Lymphoblastic Leukemia (ALL) and Acute Myeloid Leukemia (AML)

Phase 2
Conditions
Acute Myeloid Leukemia (AML)
Acute Lymphoblastic Leukemia (ALL)
Interventions
First Posted Date
2022-03-22
Last Posted Date
2022-11-29
Lead Sponsor
Armaceutica, Inc.
Target Recruit Count
200
Registration Number
NCT05291390
Locations
🇸🇳

Dalal Jamm Hospital, Guediawaye GOL SUD, Dakar, Senegal

A Study of HYML-122 in Patients With FLT3 Positive Relapsed or Refractory Acute Myeloid Leukemia (AML)

Phase 2
Recruiting
Conditions
Relapsed or Refractory Acute Myeloid Leukemia (AML)
Interventions
First Posted Date
2022-02-15
Last Posted Date
2024-05-14
Lead Sponsor
Tarapeutics Science Inc.
Target Recruit Count
15
Registration Number
NCT05241106
Locations
🇨🇳

the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China

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