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A Study Evaluating the Safety and Pharmacokinetics of ABBV-744 in Participants With Relapsed/Refractory Acute Myeloid Leukemia (AML) Cancer

Phase 1
Terminated
Conditions
Acute Myeloid Leukemia (AML)
Interventions
First Posted Date
2017-12-02
Last Posted Date
2021-03-24
Lead Sponsor
AbbVie
Target Recruit Count
30
Registration Number
NCT03360006
Locations
🇺🇸

UC Irvine /ID# 160789, Orange, California, United States

🇺🇸

University of California, Davis Comprehensive Cancer Center /ID# 202729, Sacramento, California, United States

🇺🇸

Northwestern /ID# 171098, Chicago, Illinois, United States

and more 4 locations

DLAAG in the Treatment of Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome With Blast Excess

Phase 2
Conditions
Acute Myeloid Leukemia
Myelodysplastic Syndrome
Interventions
First Posted Date
2017-11-29
Last Posted Date
2017-11-29
Lead Sponsor
Shanghai Tong Ren Hospital
Target Recruit Count
50
Registration Number
NCT03356080
Locations
🇨🇳

Beijing Friendship Hospital, Beijing, China

🇨🇳

Fujian Medical University Union Hospital, Fuzhou, China

🇨🇳

The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China

and more 3 locations

Safety and Pharmacokinetics of Intravenous and Oral APX001 in Patients With Acute Myeloid Leukemia (AML) and Neutropenia

Phase 1
Completed
Conditions
Acute Myeloid Leukemia
Interventions
Drug: APX001 with Standard of Care anti-fungal agent
First Posted Date
2017-11-06
Last Posted Date
2024-05-17
Lead Sponsor
Basilea Pharmaceutica
Target Recruit Count
20
Registration Number
NCT03333005
Locations
🇩🇪

University of Cologne, Center for Integrated Oncology (CIO), Cologne, Germany

🇩🇪

Johannes Gutenberg, University of Mainz, Mainz, Germany

🇩🇪

University of Munich, Grosshadern Campus, Munich, Germany

Study of Liposomal Annamycin for the Treatment of Subjects With Acute Myeloid Leukemia (AML)

Phase 1
Completed
Conditions
Leukemia, Myeloid, Acute
Interventions
First Posted Date
2017-10-19
Last Posted Date
2022-03-10
Lead Sponsor
Moleculin Biotech, Inc.
Target Recruit Count
7
Registration Number
NCT03315039
Locations
🇺🇸

UC San Diego Health, La Jolla, California, United States

🇺🇸

University of Florida, Gainesville, Florida, United States

🇺🇸

University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States

and more 1 locations

Onvansertib in Combination With Either Low-dose Cytarabine or Decitabine in Adult Patients With Acute Myeloid Leukemia (AML)

Phase 1
Completed
Conditions
Acute Myeloid Leukemia
Interventions
First Posted Date
2017-10-06
Last Posted Date
2023-02-27
Lead Sponsor
Cardiff Oncology
Target Recruit Count
72
Registration Number
NCT03303339
Locations
🇺🇸

University of California Los Angeles, Los Angeles, California, United States

🇺🇸

Yale University, New Haven, Connecticut, United States

🇺🇸

University of Kansas Cancer Center, Westwood, Kansas, United States

and more 6 locations

A Study of DCLL9718S in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML) or DCLL9718S in Combination With Azacitidine in Participants With Previously Untreated AML Unsuitable for Intensive Induction Chemotherapy

Phase 1
Completed
Conditions
Leukemia, Myeloid, Acute
Interventions
First Posted Date
2017-10-02
Last Posted Date
2019-11-19
Lead Sponsor
Genentech, Inc.
Target Recruit Count
19
Registration Number
NCT03298516
Locations
🇺🇸

City of Hope, Duarte, California, United States

🇺🇸

University of Colorado Hospital - Anschutz Cancer Pavilion, Aurora, Colorado, United States

🇺🇸

Yale School of Medicine, New Haven, Connecticut, United States

and more 5 locations

Ph I Study of Alvocidib and Cytarabine/Daunorubicin (7+3) in Patients With Newly Diagnosed Acute Myeloid Leukemia (AML).

Phase 1
Completed
Conditions
Acute Myeloid Leukemia
Interventions
First Posted Date
2017-10-02
Last Posted Date
2023-11-15
Lead Sponsor
Sumitomo Pharma America, Inc.
Target Recruit Count
32
Registration Number
NCT03298984
Locations
🇺🇸

Sidney Kimmel Cancer Center at Johns Hopkins, Baltimore, Maryland, United States

🇺🇸

Columbia University, New York, New York, United States

🇺🇸

University of North Carolina, Chapel Hill, North Carolina, United States

A Study of the Safety and Pharmacokinetics of Venetoclax in Pediatric and Young Adult Patients With Relapsed or Refractory Malignancies

Phase 1
Completed
Conditions
Malignancies
Acute Lymphoblastic Leukemia (ALL)
Acute Myeloid Leukemia (AML)
Non-Hodgkin's Lymphoma
Neuroblastoma
Interventions
Drug: chemotherapy
First Posted Date
2017-08-02
Last Posted Date
2023-05-22
Lead Sponsor
AbbVie
Target Recruit Count
143
Registration Number
NCT03236857
Locations
🇺🇸

Univ California, San Francisco /ID# 163460, San Francisco, California, United States

🇺🇸

Children's Hospital Colorado /ID# 161551, Aurora, Colorado, United States

🇺🇸

Children's Healthcare of Atlan /ID# 161552, Atlanta, Georgia, United States

and more 28 locations

Study of Emerfetamab (AMG 673) in Adults With Relapsed/Refractory Acute Myeloid Leukemia (AML)

Early Phase 1
Terminated
Conditions
Acute Myeloid Leukemia
Interventions
First Posted Date
2017-07-21
Last Posted Date
2023-09-01
Lead Sponsor
Amgen
Target Recruit Count
46
Registration Number
NCT03224819
Locations
🇺🇸

University of Alabama at Birmingham, Birmingham, Alabama, United States

🇺🇸

City of Hope National Medical Center, Duarte, California, United States

🇺🇸

University of Texas MD Anderson Cancer Center, Houston, Texas, United States

and more 4 locations

Study of AZD5991 Alone or in Combination With Venetoclax in Relapsed or Refractory Haematologic Malignancies.

Phase 1
Terminated
Conditions
Relapsed or Refractory Acute Myeloid Leukemia (AML)
Interventions
Drug: AZD5991 + Venetoclax
First Posted Date
2017-07-14
Last Posted Date
2022-09-23
Lead Sponsor
AstraZeneca
Target Recruit Count
70
Registration Number
NCT03218683
Locations
🇺🇸

Research Site, Houston, Texas, United States

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