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The Rapid Study: Randomized Phase II Study To Expedite Allogeneic Transplant With Immediate Haploidentical Plus Unrelated Cord Donor Search Versus Matched Unrelated Donor Search For AML And High-Risk MDS Patients

Phase 2
Terminated
Conditions
Acute Myeloid Leukemia (AML)
Myelodysplastic Syndrome (MDS)
First Posted Date
2016-01-07
Last Posted Date
2021-03-18
Lead Sponsor
University of Chicago
Target Recruit Count
9
Registration Number
NCT02648932
Locations
🇺🇸

University of Chicago Cancer Center, Chicago, Illinois, United States

A Study of CC-90002 in Subjects With Acute Myeloid Leukemia (AML) and High-risk Myelodysplastic Syndrome (MDS)

Phase 1
Terminated
Conditions
Leukemia, Myeloid, Acute
Myelodysplastic Syndromes
Interventions
First Posted Date
2015-12-29
Last Posted Date
2018-10-18
Lead Sponsor
Celgene
Target Recruit Count
28
Registration Number
NCT02641002
Locations
🇺🇸

Mayo Clinic Phoenix, Phoenix, Arizona, United States

🇺🇸

UCLA Division of Hematology Oncology, Los Angeles, California, United States

🇺🇸

Yale Cancer Center, New Haven, Connecticut, United States

and more 3 locations

A Phase 1 study to test the safety of an oral investigational drug (either AG-120 or AG-221) in combination with standard chemotherapeutic treatment for patients newly diagnosed with a blood malignancy (AML) with an IDH1 mutation and/or IDH2 mutation

Phase 1
Active, not recruiting
Conditions
Newly Diagnosed Acute Myeloid Leukemia with an IDH1 and/or IDH2 Mutation
Interventions
First Posted Date
2024-09-23
Last Posted Date
2025-04-30
Lead Sponsor
Institut De Recherches Internationales Servier IRIS
Target Recruit Count
2
Registration Number
2024-511380-29-00
Locations
🇳🇱

Stichting Amsterdam UMC, Amsterdam, Netherlands

A Trial to Find and Investigate a Safe Dose of BI 836858 in Combination With Decitabine for Patients With Acute Myeloid Leukemia (AML)

Phase 1
Completed
Conditions
Leukemia, Myeloid, Acute
Interventions
First Posted Date
2015-12-17
Last Posted Date
2024-03-19
Lead Sponsor
Boehringer Ingelheim
Target Recruit Count
49
Registration Number
NCT02632721
Locations
🇺🇸

Mayo Clinic Cancer Center, Jacksonville, Florida, United States

🇺🇸

Northwestern University, Chicago, Illinois, United States

🇺🇸

Northwell Health, Lake Success, New York, United States

and more 11 locations

Reduced-Intensity Conditioning (RIC) and Myeloablative Conditioning (MAC) for HSCT in AML/MDS

Phase 2
Completed
Conditions
Acute Myeloid Leukemia (AML)
Hematopoietic Stem Cell Transplant (HSCT)
Myelodysplastic Syndrome (MDS)
Interventions
Drug: Reduced-Intensity Conditioning Regimen
Drug: Myeloablative Conditioning Regimen
First Posted Date
2015-12-10
Last Posted Date
2024-07-16
Lead Sponsor
Randy Windreich
Target Recruit Count
21
Registration Number
NCT02626715
Locations
🇺🇸

UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States

Pilot Study of Crenolanib Combined With Standard Salvage Chemotherapy in Subjects With R/R AML

Phase 1
Completed
Conditions
Relapsed/Refractory Acute Myeloid Leukemia (AML)
Interventions
First Posted Date
2015-12-10
Last Posted Date
2023-12-20
Lead Sponsor
Arog Pharmaceuticals, Inc.
Target Recruit Count
16
Registration Number
NCT02626338
Locations
🇺🇸

University of Arkansas, Little Rock, Arkansas, United States

🇺🇸

City of Hope Medical Center, Duarte, California, United States

🇺🇸

University of Texas Southwestern Medical Center, Dallas, Texas, United States

and more 1 locations

Midostaurin Access Program for Newly Diagnosed FLT3 (ITD or TKD) Mutated AML Adult Patients Eligible for Standard Induction and Consolidation Chemotherapy

Conditions
FLT3 Mutation, Internal Tandem Duplication (ITD) or Tyrosine Kinase Domain (TKD)
Acute Myeloid Leukemia (AML) With
First Posted Date
2015-12-08
Last Posted Date
2020-07-15
Lead Sponsor
Novartis Pharmaceuticals
Registration Number
NCT02624570
Locations
🇺🇸

Mayo Clinic Arizona, Phoenix, Arizona, United States

🇺🇸

The Jordan Research and Education Center ABSMC Comprehensive Cancer Ctr, Berkeley, California, United States

🇺🇸

City of Hope National Medical Center Department of Hematology & HCT, Duarte, California, United States

and more 41 locations

A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Escalating Doses of AGS67E Given as Monotherapy in Subjects With Acute Myeloid Leukemia (AML)

Phase 1
Terminated
Conditions
Acute Myeloid Leukemia
Interventions
Drug: AGS67E
First Posted Date
2015-11-20
Last Posted Date
2024-11-01
Lead Sponsor
Astellas Pharma Global Development, Inc.
Target Recruit Count
23
Registration Number
NCT02610062
Locations
🇺🇸

Site US0006, Duarte, California, United States

🇺🇸

Site US0004, New York, New York, United States

🇺🇸

Site US0001, Houston, Texas, United States

and more 1 locations

Study of ADCT-301 in Patients With Relapsed/Refractory CD25-positive Acute Myeloid Leukemia (AML) or CD25-positive Acute Lymphoblastic Leukemia (ALL)

Phase 1
Terminated
Conditions
Acute Myeloid Leukemia
Acute Lymphoblastic Leukemia
Interventions
First Posted Date
2015-10-27
Last Posted Date
2020-02-26
Lead Sponsor
ADC Therapeutics S.A.
Target Recruit Count
35
Registration Number
NCT02588092
Locations
🇺🇸

Winship Cancer Institute, Emory University, Atlanta, Georgia, United States

🇺🇸

Northside Hospital, Atlanta, Georgia, United States

🇺🇸

The University of Chicago Medical Center, Chicago, Illinois, United States

and more 8 locations

Lintuzumab-Ac225 in Older Acute Myeloid Leukemia (AML) Patients

Phase 1
Completed
Conditions
AML
Interventions
First Posted Date
2015-10-15
Last Posted Date
2023-07-20
Lead Sponsor
Actinium Pharmaceuticals
Target Recruit Count
40
Registration Number
NCT02575963
Locations
🇺🇸

UCLA Medical Center, Division of Hematology/Oncology, Los Angeles, California, United States

🇺🇸

University of Kentucky, Markey Cancer Center, Lexington, Kentucky, United States

🇺🇸

University of Louisville, James Graham Brown Cancer Center, Louisville, Kentucky, United States

and more 14 locations

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