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The ARCT-154 Self-Amplifying RNA Vaccine Efficacy Study (ARCT-154-01)

Phase 2
Completed
Conditions
COVID-19 Vaccines
Interventions
Biological: ARCT-154 Self-Amplifying RNA SARS-CoV-2 Vaccine
Other: Placebo (normal saline)
Biological: Astra Zeneca COVID-19 vaccine
First Posted Date
2021-08-19
Last Posted Date
2023-10-16
Lead Sponsor
Vinbiocare Biotechnology Joint Stock Company
Target Recruit Count
19494
Registration Number
NCT05012943
Locations
🇻🇳

Pasteur Institute, Ho Chi Minh City, Ho Chi Minh, Vietnam

🇻🇳

Military Medical University, Ha Noi, Vietnam

🇻🇳

Hanoi Medical University, Ha Noi, Vietnam

Safety and Immunogenicity of RNA-based Vaccines Against SARS-CoV-2 Variants in Healthy Participants

Phase 2
Completed
Conditions
SARS-CoV-2 Infection
COVID-19
SARS-CoV-2 Acute Respiratory Disease
SARS (Disease)
Interventions
Biological: Monovalent BNT162b2 (B.1.617.2)
Other: Observational
Biological: Monovalent BNT162b2 (B.1.1.529.1)
Biological: Multivalent BNT162b2 (B.1.1.7 + B.1.617.2)
Biological: Monovalent BNT162b2 (B.1.1.7)
First Posted Date
2021-08-13
Last Posted Date
2024-11-22
Lead Sponsor
BioNTech SE
Target Recruit Count
1380
Registration Number
NCT05004181
Locations
🇺🇸

Stamford Therapeutics Consortium, Stamford, Connecticut, United States

🇺🇸

North Texas Infectious Diseases Consultants, Dallas, Texas, United States

🇺🇸

Atlanta Center for Medical Research, Atlanta, Georgia, United States

and more 32 locations

Study of the Composition and Bacterial Diversity of the Vaginal Microbiota in Healthy Versus Pathological Conditions (Bacterial Vaginosis) Using a Targeted Metagenomic Approach (RNA 16s)

Not Applicable
Completed
Conditions
Vaginosis, Bacterial
Interventions
Diagnostic Test: vaginal swabs
First Posted Date
2021-08-04
Last Posted Date
2021-12-14
Lead Sponsor
Larena SAS
Target Recruit Count
61
Registration Number
NCT04989543
Locations
🇫🇷

Institut FOURNIER, Paris, France

RNA-seq Analysis of PBMC in Patients With OPLL

Conditions
Bioinformatics
OPLL
PBMCs
Transcriptome
First Posted Date
2021-07-15
Last Posted Date
2021-07-15
Lead Sponsor
Fifth Affiliated Hospital, Sun Yat-Sen University
Target Recruit Count
30
Registration Number
NCT04963101
Locations
🇨🇳

Facility, Zhuhai, Guangdong, China

RENEW: Feasibility of CMV RNA-Pulsed Dendritic Cells Vaccines for the Treatment of Newly Diagnosed Glioblastoma Patients.

Phase 1
Terminated
Conditions
Glioblastoma
Interventions
Biological: Autologous DCs derived from PBMC loaded with RNA encoding the human CMV matrix protein pp65-flLAMP plus GM-CSF
First Posted Date
2021-07-15
Last Posted Date
2024-11-19
Lead Sponsor
University of Florida
Target Recruit Count
6
Registration Number
NCT04963413
Locations
🇺🇸

University of Florida Health Shands Hospital, Gainesville, Florida, United States

A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus

Phase 3
Recruiting
Conditions
Lupus Erythematosus, Systemic
Interventions
Drug: Placebo
First Posted Date
2021-07-14
Last Posted Date
2025-01-24
Lead Sponsor
Biogen
Target Recruit Count
540
Registration Number
NCT04961567
Locations
🇺🇸

RASF - Clinical Research Center, Boca Raton, Florida, United States

🇺🇸

University of Florida, Gainesville, Florida, United States

🇺🇸

Arthritis & Osteoporosis Associates, PA, Freehold, New Jersey, United States

and more 174 locations

Collection of RNA Extracted From Nasopharyngeal and Saliva Samples From Same Patients With Suspicion of Covid-19

Completed
Conditions
Respiratory Tract Infections
Interventions
Other: saliva sampling
First Posted Date
2021-07-02
Last Posted Date
2023-03-09
Lead Sponsor
ID Solutions
Target Recruit Count
2000
Registration Number
NCT04949074
Locations
🇫🇷

Bioaxiome, Nîmes, France

Pulmonary Vascular Hemodynamics Before and After Mitral Valve Procedures

Recruiting
Conditions
Pulmonary Hypertension
Interventions
Diagnostic Test: To discern micro-RNA specific for right and left heart induced PH
First Posted Date
2021-07-01
Last Posted Date
2024-08-28
Lead Sponsor
University of Alabama at Birmingham
Target Recruit Count
120
Registration Number
NCT04947384
Locations
🇺🇸

The University of Alabama at Birmingham, Birmingham, Alabama, United States

Prospective Validation of the Prognostic Value of Long Non-coding MFI2-AS1 RNA in Localized Clear Cell Kidney Cancers

Recruiting
Conditions
Kidney Cancer
First Posted Date
2021-06-30
Last Posted Date
2022-01-05
Lead Sponsor
University Hospital, Strasbourg, France
Target Recruit Count
260
Registration Number
NCT04946266
Locations
🇫🇷

Les Hôpitaux Universitaires de Strasbourg, Strasbourg, France

Treating Hepatitis C in Pakistan. Strategies to Avoid Resistance to Antiviral Drugs

Recruiting
Conditions
Hepatitis C, Chronic
Interventions
Diagnostic Test: HCV RNA (PCR)
Diagnostic Test: HCV Antibody test (Point of care)
Diagnostic Test: AST/ALT and platelets measurement
First Posted Date
2021-06-29
Last Posted Date
2025-03-24
Lead Sponsor
Queen Mary University of London
Target Recruit Count
25000
Registration Number
NCT04943588
Locations
🇵🇰

Aga Khan University, Karachi, Pakistan

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