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A Dose Escalation and Safety Study of I5NP in Patients Undergoing Major Cardiovascular Surgery

Phase 1

Completed

Conditions: Injury of Kidney
Acute Renal Failure

Interventions: Drug: I5NP (a small interfering RNA)
Drug: placebo

First Posted Date: 2007-11-06

Last Posted Date: 2011-02-23

Lead Sponsor: Quark Pharmaceuticals

Target Recruit Count: 16

Registration Number: NCT00554359

Locations: 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
🇺🇸
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
🇺🇸
University of Virginia School of Medicine, Charlottesville, Virginia, United States

and more 8 locations

Evaluation of HIV-1, HCV and HBV Blood Screening Tests With Human Blood Donor Specimens

Not Applicable

Completed

Conditions: Screening for the Presence of HIV-1, RNA and HBV DNA in Blood Donations

Interventions: Device: Blood test

First Posted Date: 2007-11-01

Last Posted Date: 2021-02-21

Lead Sponsor: Novartis

Target Recruit Count: 10290

Registration Number: NCT00552214

Locations: 🇨🇳
Taipei Blood Center Taiwan Blood Service Foundation (TBSF), Taipei, Taiwan

A Rollover Study for Subjects Participating in the Control Arm of Study VX06-950-106, VX05-950-104 and VX05-950-104EU Whose Plasma Hepatitis C Virus (HCV) Ribonucleic Acid (RNA) Levels Did Not Respond to Therapy

Phase 2

Completed

Conditions: Hepatitis C

Interventions: Drug: Telaprevir
Drug: Ribavirin
Drug: Pegylated interferon alfa 2a

First Posted Date: 2007-09-26

Last Posted Date: 2014-08-05

Lead Sponsor: Vertex Pharmaceuticals Incorporated

Target Recruit Count: 117

Registration Number: NCT00535847

Locations: 🇺🇸
Atlanta Gastroenterology Associates, Atlanta, Georgia, United States
🇺🇸
South Denver Gastroenterology, Englewood, Colorado, United States
🇺🇸
University of Florida, Gainesville, Florida, United States

and more 38 locations

HSV-2 Suppression to Reduce Maternal HIV-1 RNA Levels During Pregnancy and Breastfeeding

Phase 2

Completed

Conditions: HIV Infections
Herpes Simplex

Interventions: Drug: valacyclovir
Drug: placebo

First Posted Date: 2007-09-17

Last Posted Date: 2018-12-19

Lead Sponsor: University of Washington

Target Recruit Count: 148

Registration Number: NCT00530777

Locations: 🇰🇪
Mathare North City Clinic, Nairobi, Kenya

A Prospective Study to Evaluate the Specificity of the Cobas TaqScreen MPX Test for Use on the Cobas s 201 System for Screening Plasma Pools From Source Plasma Donors for the Presence of HBV DNA, HCV RNA, and HIV-1 RNA

Not Applicable

Completed

Conditions: Healthy Volunteer

Interventions: Device: cobas s 201 TaqScreen MPX Test

First Posted Date: 2007-08-23

Last Posted Date: 2016-03-02

Lead Sponsor: Hoffmann-La Roche

Target Recruit Count: 100000

Registration Number: NCT00520273

Multicenter Pilot Study To Define The Marker As An Alternate For Tropism Assay

Phase 1

Terminated

Conditions: HIV Infections

Interventions: Drug: maraviroc
Procedure: Trofile Assay and HIV RNA quantification assay

First Posted Date: 2007-07-04

Last Posted Date: 2019-01-30

Lead Sponsor: ViiV Healthcare

Target Recruit Count: 16

Registration Number: NCT00496782

Locations: 🇨🇦
Pfizer Investigational Site, Montreal, Quebec, Canada

Decitabine in Treating Patients With Previously Untreated Acute Myeloid Leukemia

Phase 2

Completed

Conditions: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
Secondary Acute Myeloid Leukemia
Untreated Adult Acute Myeloid Leukemia
Adult Acute Myeloid Leukemia With Del(5q)
Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)
Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)

Interventions: Drug: decitabine
Other: laboratory biomarker analysis
Other: pharmacological study
Other: high performance liquid chromatography
Genetic: microarray analysis
Genetic: RNA analysis
Other: mass spectrometry
Genetic: DNA methylation analysis
Other: matrix-assisted laser desorption/ionization time of flight mass spectrometry

First Posted Date: 2007-06-27

Last Posted Date: 2016-06-27

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 55

Registration Number: NCT00492401

Locations: 🇺🇸
Ohio State University Medical Center, Columbus, Ohio, United States

Sorafenib Tosylate and Gene Expression Analysis in Patients Undergoing Surgery For High-Risk Localized Prostate Cancer

Phase 2

Completed

Conditions: Stage II Prostate Cancer
Adenocarcinoma of the Prostate
Stage III Prostate Cancer

Interventions: Drug: sorafenib tosylate
Genetic: microarray analysis
Other: immunohistochemistry staining method
Genetic: gene expression analysis
Procedure: needle biopsy
Procedure: therapeutic conventional surgery
Other: laboratory biomarker analysis
Genetic: western blotting
Genetic: RNA analysis