Risperidone

Generic Name
Risperidone
Brand Names
Perseris, Risperdal, Rykindo, Uzedy, Okedi
Drug Type
Small Molecule
Chemical Formula
C23H27FN4O2
CAS Number
106266-06-2
Unique Ingredient Identifier
L6UH7ZF8HC
Background

Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. Paliperidone, another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone).
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Indication

Risperidone is indicated for the treatment of schizophrenia and irritability associated with autistic disorder. It is also indicated as monotherapy, or adjunctly with lithium or valproic acid, for the treatment of acute mania or mixed episodes associated with bipolar I disorder.
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Associated Conditions
Acute Mania, Irritability, Mixed manic depressive episode, Psychosis, Schizophrenia, Acute Manic episode, Agitated psychotic state
Associated Therapies
-

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3
Terminated
Conditions
Interventions
Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium
First Posted Date
2015-03-02
Last Posted Date
2018-02-28
Lead Sponsor
Hannover Medical School
Target Recruit Count
407
Registration Number
NCT02374567
Locations
🇩🇪

Bezirkskrankenhaus Augsburg, Augsburg, Germany

🇩🇪

Krankenhaus Hedwigshöhe, Berlin, Germany

🇩🇪

Hannover Medical School, Hannover, Germany

and more 2 locations

Comparison of Aripiprazole Versus Risperidone on Brain Morphology Using MRI

First Posted Date
2015-01-08
Last Posted Date
2016-06-01
Lead Sponsor
University of British Columbia
Target Recruit Count
60
Registration Number
NCT02334904
Locations
🇨🇦

BC Mental Health & Addictions Research Institute, Vancouver, British Columbia, Canada

Efficacy of Repetitive Transcranial Magnetic Stimulation in the Prevention of Relapse of Schizoaffective

First Posted Date
2014-08-20
Last Posted Date
2014-08-20
Lead Sponsor
Xijing Hospital
Target Recruit Count
540
Registration Number
NCT02221635
Locations
🇨🇳

Qingrong, Xi'an, Shaanxi, China

A Randomized Double-blind Trial With 6 Antipsychotic Drugs for Schizophrenia

First Posted Date
2014-07-17
Last Posted Date
2016-07-12
Lead Sponsor
Beijing HuiLongGuan Hospital
Target Recruit Count
550
Registration Number
NCT02192723
Locations
🇨🇳

Beijing HuiLongGuan Hospital, Beijing, China

Antipsychotic to Treat Psychosis Syndrome

First Posted Date
2014-05-14
Last Posted Date
2014-05-14
Lead Sponsor
Central South University
Target Recruit Count
300
Registration Number
NCT02137616
Locations
🇨🇳

the Second Xiangya Hospital, Changsha, Hunan, China

Efficacy and Safety of Risperidone and Trazodone Monotherapy and Combination Therapy in Critically Ill Patients With Delirium

First Posted Date
2014-04-21
Last Posted Date
2019-09-10
Lead Sponsor
Rochester General Hospital
Registration Number
NCT02118688
Locations
🇺🇸

Rochester General Hospital, Rochester, New York, United States

Randomized, Double-blind, Placebo Controlled, Multi-center and Tolerability of RBP-7000 in Schizophrenia Patients

Phase 3
Completed
Conditions
Interventions
First Posted Date
2014-04-10
Last Posted Date
2018-10-26
Lead Sponsor
Indivior Inc.
Target Recruit Count
354
Registration Number
NCT02109562
Locations
🇺🇸

Pillar Clinic Research, LLC, Dallas, Texas, United States

🇺🇸

Comprehensive Clinical Development - Cerritos, CA, Cerritos, California, United States

🇺🇸

Synergy Clinical Research of Escondido, Escondido, California, United States

and more 26 locations

Methylphenidate vs. Risperidone for the Treatment of Children and Adolescents With ADHD and Disruptive Disorders

First Posted Date
2014-02-17
Last Posted Date
2020-03-18
Lead Sponsor
Sheba Medical Center
Target Recruit Count
5
Registration Number
NCT02063945
Locations
🇮🇱

Sheba medical center, Tel Hashomer, Israel

Cannabidiol as a Different Type of an Antipsychotic: Drug Delivery and Interaction Study

First Posted Date
2014-01-31
Last Posted Date
2018-03-08
Lead Sponsor
Central Institute of Mental Health, Mannheim
Target Recruit Count
74
Registration Number
NCT02051387
Locations
🇩🇪

Dept. of Pharmacology, University of Cologne, Cologne, NRW, Germany

🇩🇪

Central Institute of Mental Health, Mannheim, BW, Germany

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