Cysteine

Generic Name: Cysteine

Brand Names: Elcys, Freamine 6.9, Freamine III 10, Hepatamine 8, Nephramine, Nouress, Premasol, Primene, Procalamine 3, Trophamine 10 %

Drug Type: Small Molecule

Chemical Formula: C_₃H_₇NO_₂S

CAS Number: 52-90-4

Unique Ingredient Identifier: K848JZ4886

Background: A thiol-containing non-essential amino acid that is oxidized to form cystine.

Indication: For the prevention of liver damage and kidney damage associated with overdoses of acetaminophen

Associated Therapies: Total parenteral nutrition therapy, Amino acid supplementation

Clinical Trials

A Confirmatory Trial of Adjunctive NAC to Prevent Post Tuberculosis Lung Disease

Not Applicable

Recruiting

Conditions: Tuberculosis (TB)

Interventions: Drug: N-Acetyl Cysteine (NAC)
Drug: Standard TB treatment

First Posted Date: 2025-04-04

Last Posted Date: 2025-04-30

Lead Sponsor: The Aurum Institute NPC

Target Recruit Count: 242

Registration Number: NCT06909799

Locations: 🇬🇲
MRC Unit The Gambia at LSHTM, Fajara, The Gambia, Gambia

The Combined Effect of N-Acetyl Cysteine and Metformin in Polycystic Ovary Syndrome Patients

Phase 3

Not yet recruiting

Conditions: Polycystic Ovary Syndrome

Interventions: Drug: N-acetyl cysteine
Drug: Metfomin

First Posted Date: 2025-02-20

Last Posted Date: 2025-02-20

Lead Sponsor: Cairo University

Target Recruit Count: 102

Registration Number: NCT06836128

Locations: 🇪🇬
Kasr El-Ainy hospital, Cairo, Egypt

Chlorhexidine Versus N-Asetil Sistein Irrigation in Mandibular Molar Teeth with Chronic Apical Periodontitis

Not Applicable

Completed

Conditions: Chronic Apical Periodontitis

Interventions: Drug: Chlorhexidine
Drug: N-Acetyl Cysteine

First Posted Date: 2025-02-19

Last Posted Date: 2025-02-20

Lead Sponsor: Cukurova University

Target Recruit Count: 78

Registration Number: NCT06834711

Locations: 🇹🇷
Cukurova University, Adana, Sarıçam, Turkey

N-acetyl Cysteine Effect on Liver Function After Mitral Valve Replacement

Phase 4

Completed

Conditions: Oxidative Stress
Liver Dysfunction

Interventions: Drug: N acetyl cysteine
Other: normal saline

First Posted Date: 2024-07-05

Last Posted Date: 2025-01-17

Lead Sponsor: Kasr El Aini Hospital

Target Recruit Count: 40

Registration Number: NCT06486805

Locations: 🇪🇬
Kasralainy Faculty of Medicine, Cairo, Egypt

Gene-guided N-acetyl Cysteine for Prophylaxis of Anti-tuberculous Drug- Induced Hepatitis

Phase 4

Recruiting

Conditions: Tuberculosis (TB)
Isoniazid Toxicity
Rifampicin Toxicity
Pyrazinamide Adverse Reaction
Ethambutol Toxicity
NAT2 Slow Acetylator Status
NAT2 Rapid Acetylator Status
NAT2 Polymorphism
N-Acetylcysteine

Interventions: Drug: N acetyl cysteine

First Posted Date: 2024-07-03

Last Posted Date: 2024-07-03

Lead Sponsor: Mahidol University

Target Recruit Count: 116

Registration Number: NCT06484530

Locations: 🇹🇭
Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok Noi, Bangkok, Thailand

Effect of N-acetyl Cysteine and Zinc in Management of Head and Neck Cancer Radiotherapy Induced Oral Mucositis

Phase 2

Completed

Conditions: Radiation-Induced Mucositis

Interventions: Drug: N-acetyl cysteine
Drug: saline mouth wash
Drug: Zinc sulfate

First Posted Date: 2024-07-01

Last Posted Date: 2024-12-31

Lead Sponsor: Mansoura University

Target Recruit Count: 50

Registration Number: NCT06482034

Locations: 🇪🇬
Mansoura university, Mansoura, Egypt

Combination of Vitamin C and N-Acetylcysteine to Improve Functional Outcome After Rotator Cuff Repair

Phase 4

Not yet recruiting

Conditions: Rotator Cuff Tears

Interventions: Other: placebo
Drug: Ascorbic acid
Drug: N-acetyl cysteine

First Posted Date: 2024-04-25

Last Posted Date: 2024-04-25

Lead Sponsor: Mahidol University

Target Recruit Count: 110

Registration Number: NCT06384833

Evaluation of the Effect of N-acetylcysteine in Preventing Cisplatin-Induced Toxicities in Cancer Patients

Phase 2

Recruiting

Conditions: Cisplatin Ototoxicity
Cisplatin Adverse Reaction
Cancer Patients
Cisplatin Nephrotoxicity
Cisplatin Induced Peripheral Neuropathy

Interventions: Drug: N acetyl cysteine

First Posted Date: 2024-03-07

Last Posted Date: 2024-03-07

Lead Sponsor: Ain Shams University

Target Recruit Count: 60

Registration Number: NCT06297369

Locations: 🇪🇬
Department of Clinical Oncology and Nuclear Medicine, Ain Shams University Hospitals, Cairo, Egypt., Cairo, Egypt

Comparative Clinical Study to Evaluate the Possible Efficacy and Safety of Oral N-Acetyl Cysteine Versus Rectal Diclofenac in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis

Phase 1

Recruiting

Conditions: Post ERCP Pancreatitis

Interventions: Drug: Oral N-acetyl cysteine
Drug: Rectal Diclofenac

First Posted Date: 2024-02-09

Last Posted Date: 2024-02-09

Lead Sponsor: Tanta University

Target Recruit Count: 46

Registration Number: NCT06252441

Locations: 🇪🇬
Obstructive Jaundice Clinic in the National Liver Institute, Menoufia University , Shebin Elkoom, Menofia, Egypt

Effect of Oral N-Acetyl Cysteine in Prevention of Necrotizing Enterocolitis in Preterm Neonates With Feeding Intolerance

Phase 4

Active, not recruiting

Conditions: Preterm Neonates and Feeding Intolerance
Necrotizing Enterocolitis
Oral N-acetyl Cysteine

Interventions: Other: placebo
Drug: oral n-acetyl cysteine

First Posted Date: 2024-01-12

Last Posted Date: 2024-01-12

Lead Sponsor: Ain Shams University

Target Recruit Count: 100

Registration Number: NCT06202911

Locations: 🇪🇬
Ain Shams university hospitals, Cairo, Egypt

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