Fluoxetine

Generic Name
Fluoxetine
Brand Names
Prozac, Sarafem, Symbyax
Drug Type
Small Molecule
Chemical Formula
C17H18F3NO
CAS Number
54910-89-3
Unique Ingredient Identifier
01K63SUP8D
Background

Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies.

Indication

Fluoxetine is indicated for both acute and maintenance treatment of major depressive disorder, obsessive compulsive disorder, and bulimia nervosa; however, it is only indicated for acute treatment of panic disorder independent of whether agoraphobia is present. Fluoxetine may also be used in combination with olanzapine to treat depression related to Bipolar ...

Associated Conditions
Alcohol Dependency, Anorexia Nervosa (AN), Bulimia Nervosa, Cataplexy, Depression, Major Depressive Disorder (MDD), Major depressive disorder, recurrent episode, Myoclonus, Obesity, Obsessive Compulsive Disorder (OCD), Panic Disorder With Agoraphobia, Panic disorder without agoraphobia, Premature Ejaculation, Premenstrual Dysphoric Disorder (PMDD)
Associated Therapies
Maintenance therapy

Deep Brain Stimulation of NAc/ALIC to Prevent Treatment-Refractory Obsessive Compulsive Disorder

First Posted Date
2015-11-10
Last Posted Date
2015-11-10
Lead Sponsor
Tang-Du Hospital
Target Recruit Count
10
Registration Number
NCT02601677

Integrating Psychotropic Medication Into the Care of People With Mental Disorders in a Prayer Camp in Ghana

First Posted Date
2015-11-01
Last Posted Date
2015-11-01
Lead Sponsor
University of Ghana Medical School
Target Recruit Count
139
Registration Number
NCT02593734
Locations
🇬🇭

Mount Horeb Prayer Centre, Mamfe, Ghana

Does Adding Oral Contraceptives to Fluoxetine Improve the Management of Premenstrual Syndrome?

First Posted Date
2015-09-29
Last Posted Date
2016-07-06
Lead Sponsor
Cairo University
Target Recruit Count
300
Registration Number
NCT02562053
Locations
🇪🇬

Cairo University Hospitals, Cairo, Egypt

🇪🇬

BeniSuef University hospitals, BeniSuef, Egypt

Combined Oral Contraceptives and Fluoxetine Versus Combined Oral Contraceptives in Severe Premenstrual Syndrome

First Posted Date
2015-07-02
Last Posted Date
2017-01-23
Lead Sponsor
Cairo University
Target Recruit Count
300
Registration Number
NCT02488538
Locations
🇪🇬

BeniSuef University hospitals, BeniSuef, Egypt

🇪🇬

Cairo University Hospitals, Cairo, Egypt

Acupuncture for Ischemic Post-stroke Depression

First Posted Date
2015-06-16
Last Posted Date
2021-02-24
Lead Sponsor
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Target Recruit Count
208
Registration Number
NCT02472613
Locations
🇨🇳

Tianjin Academy of Tradional Chinese Medicine Afflicated Hospital, Tianjin, Tianjin, China

🇨🇳

First Affiliated hospital of Tianjin University of TCM, Tianjin, Tianjin, China

🇨🇳

Beijing Hospital of Traditional Chinese Medicine, Beijing, China

Prediction of Clinical Response to SSRI Treatment in Bipolar Disorder Using Serotonin 1A Receptor PET Imaging

Phase 4
Completed
Conditions
Interventions
First Posted Date
2015-06-16
Last Posted Date
2021-04-01
Lead Sponsor
New York State Psychiatric Institute
Target Recruit Count
40
Registration Number
NCT02473250
Locations
🇺🇸

New York State Psychiatric Institute/Columbia University Medical Center, New York, New York, United States

Safety and Efficacy of Levomilnacipran ER in Adolescent Participants With Major Depressive Disorder

First Posted Date
2015-05-01
Last Posted Date
2020-09-07
Lead Sponsor
Forest Laboratories
Target Recruit Count
552
Registration Number
NCT02431806
Locations
🇺🇸

Innovative Clinical Research, Inc., Lauderhill, Florida, United States

🇺🇸

Professional Psychiatric Services, Mason, Ohio, United States

🇺🇸

Carilion Medical Center, Roanoke, Virginia, United States

and more 45 locations

Dienogest Versus Luteal Phase Fluoxetine in the Management of Premenstrual Syndrome

First Posted Date
2015-04-28
Last Posted Date
2020-12-01
Lead Sponsor
Cairo University
Target Recruit Count
210
Registration Number
NCT02427334
Locations
🇪🇬

Cairo university hospitals, Cairo, Egypt

16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression

Phase 4
Terminated
Conditions
Interventions
First Posted Date
2015-03-17
Last Posted Date
2019-06-19
Lead Sponsor
Mayo Clinic
Target Recruit Count
2
Registration Number
NCT02389712
Locations
🇺🇸

Mayo Clinic, Rochester, Minnesota, United States

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3
Terminated
Conditions
Interventions
Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium
First Posted Date
2015-03-02
Last Posted Date
2018-02-28
Lead Sponsor
Hannover Medical School
Target Recruit Count
407
Registration Number
NCT02374567
Locations
🇩🇪

Bezirkskrankenhaus Augsburg, Augsburg, Germany

🇩🇪

Krankenhaus Hedwigshöhe, Berlin, Germany

🇩🇪

Hannover Medical School, Hannover, Germany

and more 2 locations
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