Mifepristone
- Generic Name
- Mifepristone
- Brand Names
- Korlym, Mifegymiso
- Drug Type
- Small Molecule
- Chemical Formula
- C29H35NO2
- CAS Number
- 84371-65-3
- Unique Ingredient Identifier
- 320T6RNW1F
- Background
Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary c...
- Indication
For the medical termination of intrauterine pregnancy through 49 days' pregnancy. Also indicated to control hyperglycemia secondary to hypercortisolism in adult patients with endogenous Cushing's syndrome who have type 2 diabetes mellitus or glucose intolerance and are not candidates for surgery or have had unsuccessful surgery.
- Associated Conditions
- Hyperglycemia
- Associated Therapies
- Medically induced abortion
Value of Mifepristone in Cervical Preparation Prior to Dilation and Evacuation 19-24 Weeks
- Conditions
- Interventions
- First Posted Date
- 2012-06-11
- Last Posted Date
- 2024-02-13
- Lead Sponsor
- Stanford University
- Target Recruit Count
- 50
- Registration Number
- NCT01615731
- Locations
- 🇺🇸
Santa Clara Valley Medical Center, San Jose, California, United States
🇺🇸Stanford University Medical Center, Stanford, California, United States
Nab-paclitaxel (Abraxane) With or Without Mifepristone in Patients With Advanced Breast Cancer
- First Posted Date
- 2011-12-15
- Last Posted Date
- 2018-09-12
- Lead Sponsor
- University of Chicago
- Target Recruit Count
- 9
- Registration Number
- NCT01493310
- Locations
- 🇺🇸
University of Chicago, Chicago, Illinois, United States
🇺🇸NorthShore University Health System, Evanston, Illinois, United States
Developing Memory Reconsolidation Blockers as Novel Posttraumatic Stress Disorder (PTSD) Treatments
- Conditions
- Interventions
- First Posted Date
- 2011-12-13
- Last Posted Date
- 2017-06-29
- Lead Sponsor
- Roger K. Pitman, MD
- Target Recruit Count
- 34
- Registration Number
- NCT01490697
- Locations
- 🇺🇸
Dallas VA, Dallas, Texas, United States
🇺🇸Massachusetts General Hospital, Boston, Massachusetts, United States
Study on Combined Use of Letrozole, Mifepristone and Misoprostol in Termination of Pregnancy
- Conditions
- Interventions
- First Posted Date
- 2011-11-21
- Last Posted Date
- 2011-11-21
- Lead Sponsor
- The University of Hong Kong
- Target Recruit Count
- 50
- Registration Number
- NCT01475318
- Locations
- 🇭🇰
Joyce Chai, Hong Kong, Hong Kong
Mifepristone Versus Osmotic Dilator Insertion for Cervical Preparation Prior to Surgical Abortion at 15-18 Weeks
- Conditions
- Interventions
- First Posted Date
- 2011-09-19
- Last Posted Date
- 2017-06-14
- Lead Sponsor
- Boston University
- Target Recruit Count
- 50
- Registration Number
- NCT01436279
- Locations
- 🇺🇸
Boston University, Boston, Massachusetts, United States
Mifepristone Effects on Glucose Intolerance in Obese/Overweight Adults
- First Posted Date
- 2011-08-18
- Last Posted Date
- 2021-04-14
- Target Recruit Count
- 19
- Registration Number
- NCT01419535
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
Compassionate Use of CORLUX® (Mifepristone) in the Treatment of Signs and Symptoms of Endogenous Cushing's Syndrome
- First Posted Date
- 2011-06-13
- Last Posted Date
- 2014-03-18
- Lead Sponsor
- Corcept Therapeutics
- Target Recruit Count
- 4
- Registration Number
- NCT01371565
- Locations
- 🇺🇸
The Center for Diabetes and Endocrine Care, Hollywood, Florida, United States
🇺🇸Sinai Hospital of Baltimore, Baltimore, Maryland, United States
🇺🇸University of Michigan Medical Center, Ann Arbor, Michigan, United States
Antiglucocorticoid Therapy for Cognitive Impairment in Late-life Anxiety Disorders
- First Posted Date
- 2011-04-11
- Last Posted Date
- 2020-08-18
- Lead Sponsor
- Washington University School of Medicine
- Target Recruit Count
- 15
- Registration Number
- NCT01333098
- Locations
- 🇺🇸
Washington University School of Medicine, Saint Louis, Missouri, United States
Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained Men
- Conditions
- Interventions
- First Posted Date
- 2011-02-11
- Last Posted Date
- 2024-07-15
- Target Recruit Count
- 51
- Registration Number
- NCT01294319
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
The Effect of Mifepristone on the Expression of Cervical Prostaglandin EP3 Receptors
- Conditions
- Interventions
- First Posted Date
- 2010-10-20
- Last Posted Date
- 2010-10-20
- Lead Sponsor
- University of Southern California
- Target Recruit Count
- 18
- Registration Number
- NCT01224509
- Locations
- 🇺🇸
Women's and Children's Hospital, Reproductive Research Center, Los Angeles, California, United States
Drug Development Updates
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