Ifosfamide
- Generic Name
- Ifosfamide
- Brand Names
- Ifex
- Drug Type
- Small Molecule
- Chemical Formula
- C7H15Cl2N2O2P
- CAS Number
- 3778-73-2
- Unique Ingredient Identifier
- UM20QQM95Y
- Background
Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.
- Indication
Used as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer. Also used as a component of various chemotherapeutic regimens for the treatment of cervical cancer, as well as in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas. Other indi...
- Associated Conditions
- Bladder Cancer, Cervical Cancer, Ewing's Sarcoma, Head And Neck Cancer, Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma (NHL), Osteosarcoma, Ovarian Cancer, Pancreatic Cancer, Small Cell Lung Cancer (SCLC), Soft Tissue Sarcoma, Testicular Germ Cell Cancer, Thymoma
- Associated Therapies
- -
Combination Chemotherapy Plus Surgery and Radiation Therapy in Treating Patients With Ewing's Sarcoma
- Conditions
- First Posted Date
- 2004-05-05
- Last Posted Date
- 2013-09-17
- Lead Sponsor
- University Hospital Muenster
- Registration Number
- NCT00002516
- Locations
- ๐ฌ๐ง
Royal Victoria Infirmary, Newcastle-upon-Tyne, England, United Kingdom
Combination Chemotherapy and Radiation Therapy in Treating Patients With Peripheral Neuroectodermal Tumors, Ewing's Sarcoma, Wilms' Tumor, or Bone Cancer
- Conditions
- First Posted Date
- 2004-04-26
- Last Posted Date
- 2013-06-20
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Registration Number
- NCT00002466
- Locations
- ๐บ๐ธ
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcoma
- Conditions
- First Posted Date
- 2004-04-22
- Last Posted Date
- 2012-07-11
- Target Recruit Count
- 340
- Registration Number
- NCT00002764
- Locations
- ๐ธ๐ช
Lund University Hospital, Lund, Sweden
Radiolabeled Monoclonal Antibody, Combination Chemotherapy, and Peripheral Stem Cell Transplantation in Treating Patients With Recurrent or Refractory B-Cell Cancer
- Locations
- ๐บ๐ธ
Garden State Cancer Center, Belleville, New Jersey, United States
Radiation Therapy With or Without Chemotherapy After Surgery in Treating Patients With Stage IB or Stage IIA Cervical Cancer
- Conditions
- First Posted Date
- 2004-04-14
- Last Posted Date
- 2012-07-11
- Target Recruit Count
- 700
- Registration Number
- NCT00003209
- Locations
- ๐ฌ๐ง
Derbyshire Royal Infirmary, Derby, England, United Kingdom
๐ฌ๐งBeatson Oncology Centre, Glasgow, Scotland, United Kingdom
Chemotherapy Plus Peripheral Stem Cell Transplantation Compared With Chemotherapy Alone in Treating Women With Stage IV Breast Cancer
- Conditions
- First Posted Date
- 2004-04-13
- Last Posted Date
- 2014-01-06
- Lead Sponsor
- Herbert Irving Comprehensive Cancer Center
- Registration Number
- NCT00012311
- Locations
- ๐บ๐ธ
Herbert Irving Comprehensive Cancer Center, New York, New York, United States
Neoadjuvant Ifosfamide, Doxorubicin, Gemcitabine, and Cisplatin in Treating Patients Who Are Undergoing Radical Cystectomy for Locally Advanced Carcinoma (Cancer) of the Urothelium
- Conditions
- First Posted Date
- 2004-04-08
- Last Posted Date
- 2012-10-22
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 65
- Registration Number
- NCT00080795
- Locations
- ๐บ๐ธ
M.D. Anderson Cancer Center at University of Texas, Houston, Texas, United States
Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia
- Conditions
- Interventions
- Drug: cyclophosphamideDrug: cytarabineDrug: dexamethasoneDrug: doxorubicin hydrochlorideDrug: etoposideDrug: ifosfamideDrug: leucovorin calciumDrug: mesnaDrug: methotrexateDrug: prednisoneDrug: therapeutic hydrocortisoneDrug: vincristine sulfateRadiation: low-LET cobalt-60 gamma ray therapyRadiation: low-LET photon therapy
- First Posted Date
- 2004-04-06
- Last Posted Date
- 2016-07-04
- Lead Sponsor
- Alliance for Clinical Trials in Oncology
- Target Recruit Count
- 134
- Registration Number
- NCT00002494
- Locations
- ๐บ๐ธ
Marlene & Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, United States
๐บ๐ธUniversity of Massachusetts Memorial Medical Center, Worcester, Massachusetts, United States
๐บ๐ธEllis Fischel Cancer Center - Columbia, Columbia, Missouri, United States
Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Women With Metastatic Breast Cancer
- Conditions
- Locations
- ๐บ๐ธ
H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States
High-dose ICE With Amifostine
- Conditions
- Interventions
- First Posted Date
- 2004-03-31
- Last Posted Date
- 2017-01-20
- Lead Sponsor
- Dana-Farber Cancer Institute
- Target Recruit Count
- 24
- Registration Number
- NCT00003657
- Locations
- ๐บ๐ธ
Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States
๐บ๐ธBeth Israel Deaconess Medical Center, Boston, Massachusetts, United States
๐บ๐ธDana-Farber Cancer Institute, Boston, Massachusetts, United States
Drug Development Updates
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